Table 1

 Baseline characteristics of the 301 randomised and treated patients with medial knee OA with regards to the treatment group

Baseline characteristicsNRD101 (n = 131)Diacerein (n = 85)Placebo (n = 85)
Results are given as mean (SD) unless otherwise indicated.
Demographic characteristics
Age (years)64.9 (8.4)64.5 (7.8)64.9 (7.7)
Sex (% female)71.069.461.2
Weight (kg)76.8 (14.0)78.0 (13.9)79.7 (14.5)
Height (cm)164.1 (9.3)162.9 (7.9)163.5 (8.9)
Right knee, No (%)65 (50)41 (48)48 (56)
Symptomatic variables
Pain score on 0–100 VAS61.7 (13.6)59.6 (12.5)59.1 (14.7)
Functional impairment (Lequesne’s index)11.1 (2.8)10.5 (2.6)10.5 (3.1)
Patient’s global assessment (0–100 VAS)59.7 (15.9)59.0 (17.0)57.3 (18.5)
Percentage of painful days during the previous month (0–100 VAS)85.5 (20.4)83.0 (18.5)82.6 (21.0)
Structural variables (n  = 127) (n  = 82) (n  = 83)
Joint space width (mm)4.5 (1.2)4.5 (1.1)4.7 (1.3)
Osteophyte score (4 grades), No (%) (n  = 128) (n  = 84) (n  = 83)
    05 (4)4 (5)5 (6)
    153 (41)41 (49)36 (43)
    259 (46)31 (37)40 (48)
    311 (9)8 (10)2 (2)
Kellgren and Lawrence score (5 grades), No (%) (n  = 129) (n  = 84) (n  = 83)
    01 (0.8)0 (0)0 (0.00)
    14 (3)3 (4)2 (2)
    230 (23)12 (14)19 (23)
    390 (70)66 (79)60 (72)
    44 (3)3 (4)2 (2)