Table 1

 Efficacy end points used to assess etanercept

ASAS, Assessments in Ankylosing Spondylitis; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index.
I. ASAS Response Criteria: improvements of at least 20%, 50%, and 70% in at least three of these four domains:
A. Spinal inflammation: composite of two items from BASDAI—that is,
    1. Duration of morning stiffness
    2. Intensity of morning stiffness
B. Total back pain and nocturnal back pain (combined)
C. Patient global assessment of health
D. Functional impairment: composite score of 10 items on BASFI—that is,
    1. Putting on socks without aids
    2. Picking up pen from floor
    3. Reaching high shelf without aids
    4. Getting up from an armless chair
    5. Getting off floor from back
    6. Standing unsupported for at least 10 minutes
    7. Climbing 12 to 15 steps without aids
    8. Looking over shoulder
    9. Performing a demanding activity
    10. Doing a full day’s activity
II. BASDAI scores
A. Daily activity composite score
B. Scores on six separate items
    1. Fatigue
    2. AS pain in necks, back, or hips
    3. Pain in other joints
    4. Discomfort in areas tender to touch or pressure
    5. Duration of morning stiffness
    6. Intensity of morning stiffness
III. Levels of acute phase reactants
A. C reactive protein (CRP)
B. Erythrocyte sedimentation rate (ESR)
IV. Spinal mobility scores
A. Forward flexion (Schober’s test)
B. Chest expansion
C. Occiput to wall distance