Multivariate conditional logistic regression analysis of factors discriminating subjects with a parent with total knee replacement for osteoarthritis from controls
| Univariate OR (95% CI) | Multivariate* OR (95% CI) | |
|---|---|---|
| *Adjusted for factors in the table as well as for radiographic osteoarthritis (which was not a significant variable in either model). The coefficients are per unit for BMI and per SD for muscle strength and bone area. Significant values in bold. | ||
| BMI, body mass index; OR, odds ratio. | ||
| All subjects (188 pairs) | ||
| Knee pain (yes v no) | 3.10 (1.92 to 5.01) | 2.85 (1.70 to 4.78) |
| BMI (kg/m2) | 1.03 (0.99 to 1.07) | 1.01 (0.97 to 1.05) |
| Lower limb muscle strength | 0.59 (0.41 to 0.86) | 0.61 (0.40 to 0.93) |
| Medial tibial bone area | 1.44 (1.06 to 1.96) | 1.53 (1.02 to 2.29) |
| One offspring per family (111 pairs) | ||
| Knee pain (yes v no) | 2.86 (1.56 to 5.25) | 2.94 (1.36 to 6.40) |
| BMI (kg/m2) | 1.13 (1.05 to 1.23) | 1.11 (1.01 to 1.22) |
| Lower limb muscle strength | 0.59 (0.35 to 0.99) | 0.43 (0.22 to 0.85) |
| Medial tibial bone area | 2.09 (1.25 to 3.51) | 2.59 (1.36 to 4.96) |