Association between the age at disease onset and ORα polymorphism in patients with systemic lupus erythematosus
| By one way analysis of variance: | PvuII polymorphism | XbaI polymorphism | ||||
|---|---|---|---|---|---|---|
| PP | Pp | pp | XX | Xx | xx | |
| Age (years) (mean (SEM)) | 38.1 (2.9) | 24.6 (1.5) | 23.8 (2.0) | 24.0 (4.5) | 21.0 (1.6) | 28.1 (1.5) |
| p Value: | 0.001 | 0.025 | ||||
| By Tukey’s test: | PP v Pp, p = 0.001; PP v pp, p = 0.001 | Xx v xx, p = 0.02 | ||||
| By multivariate analysis: | Estimate | SEM | χ2 | p Value | Adjusted OR (95% CI) | |
|---|---|---|---|---|---|---|
| Significant results in bold. | ||||||
| *Without oral ulcer; †with oral ulcer; ‡age = 14 (1st quartile); §age = 23.2 (median); ¶age = 35.2 (3rd quartile). | ||||||
| CI, confidence interval; OR, odds ratio; ORα, oestrogen receptor α. | ||||||
| For PvuII | ||||||
| PP v pp | ||||||
| Age at onset | 0.099 | 0.034 | 8.46 | 0.0036 | 1.10 (1.04 to 1.18)* | |
| 1.03 (0.91 to 1.17)† | ||||||
| Oral ulcer | 2.148 | 1.164 | 3.40 | 0.0651 | 3.33 (0.14 to 79.20)‡ | |
| 1.79 (0.04 to 77.20)§ | ||||||
| 0.80 (0.009 to 75.20)¶ | ||||||
| Age at onset*oral ulcer | −0.067 | 0.034 | 3.93 | 0.0474 | – | |
| Pp v pp | ||||||
| Age at onset | −0.010 | 0.020 | 0.08 | 0.7824 | 0.99 (0.96 to 1.03)* | |
| 0.97 (0.91 to 1.04)† | ||||||
| Oral ulcer | 1.163 | 0.461 | 6.36 | 0.0117 | 2.30 (0.56 to 9.41)‡ | |
| 1.85 (0.32 to 10.72)§ | ||||||
| 1.39 (0.15 to 12.79)¶ | ||||||
| Age at inset*oral ulcer | −0.024 | 0.020 | 1.39 | 0.2384 | – | |
| For XbaI | ||||||
| XX v xx | ||||||
| Age at onset | −0.004 | 0.028 | 0.02 | 0.8760 | 0.99 (0.94 to 1.05) | |
| Oral ulcer | −0.594 | 0.375 | 2.51 | 0.1132 | 0.55 (0.26 to 1.15) | |
| Xx v xx | ||||||
| Age at onset | −0.052 | 0.019 | 7.47 | 0.0063 | 0.95 (0.91 to 0.99) | |
| Oral ulcer | 0.236 | 0.234 | 1.03 | 0.3131 | 1.27 (0.80 to 2.00) | |