Combinations in changes when switching first from intramuscular to oral methotrexate and then from oral to intramuscular in 47 patients with rheumatoid arthritis
| IM to oral MTX | Oral to IM MTX | Morning pain | Hand morning stiffness | Duration of morning joint stiffness | Joint pain | Joint swelling | Consumption of analgesics | Duration of analgesic consumption | Eye dryness | Mouth dryness | Nausea after MTX | Transaminase levels |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Values are n (%). | ||||||||||||
| IM, intramuscular; MTX, methotrexate. | ||||||||||||
| No change | Decrease | 1 (2) | 1 (2) | 0 | 1 (2) | 2 (4) | 1 (2) | 1 (2) | 1 (2) | 1 (3) | 0 | 0 |
| No change | No change | 19 (40) | 16 (34) | 14 (30) | 9 (19) | 14 (30) | 11 (23) | 11 (23) | 22 (47) | 19 (40) | 13 (28) | 23 (50) |
| No change | Increase | 0 | 0 | 0 | 1 (2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Increase | Decrease | 20 (43) | 23 (49) | 28 (60) | 33 (70) | 19 (40) | 30 (63) | 31 (65) | 8 (17) | 8 (17) | 19 (40) | 10 (20) |
| Increase | No change | 2 (4) | 6 (13) | 2 (4) | 3 (7) | 9 (20) | 4 (8) | 3 (6) | 0 | 1 (2) | 2 (4) | 0 |
| Increase | Increase | 0 | 0 | 1 (2) | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (2) |
| Decrease | Decrease | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (2) |
| Decrease | No change | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Decrease | Increase | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Not answered | Not answered | 5 (11) | 1 (2) | 2 (4) | 0 | 3 (6) | 2 (4) | 2 (4) | 16 (34) | 18 (38) | 13 (28) | 12 (26) |