Table 4

Comparison of effects on immature dendritic cells (iDCs) of murine BD2 and lipopolysaccharide (LPS)

LPSMBD2
IFN, interferon; IL, interleukin; TLR, toll-like receptor; TNF, tumour necrosis factor.
Induces iDC chemokine production - IL8, RANTES, MDC, IP10 and MIP1α++
Induces iDC chemokine receptor - CCR7++
Induces iDC cytokine production - IL1α, β, TNF, IL6, IL12, IFNγ++
Suppresses chemokine receptor expression - CCR2, CCR5, CCR6++
Suppresses receptor expression - mannose and scavenger R2++
Blocked by proteinase K and by boiling for 15 minNoYes
Blocked by polymixin B and diphosphoryl lipid AYesNo
Activates iDCs in serum-free mediumNoYes
Activates iDCs from CCR6 −/− miceYesYes
Activates iDCs from TLR4 mutant miceNoNo