Changes between follow ups
| Months 0–3 | Months 3–6 | Months 6–12 | Months 12–18 | Months 18–24 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | p | Mean (SD) | p | Mean (SD) | p | Mean (SD) | p | Mean (SD) | p | |
| Swollen joints (28) | ||||||||||
| Women | −4.5 (6) | 0.0001 | −0.2 (4) | NS | −0.1 (4) | NS | −0.1 (5) | NS | −0.1 (4) | NS |
| Men | −5.7 (6) | 0.0001 | −0.7 (5) | NS | −1.1 (5) | NS | +0.4 (4) | NS | +0.4 (5) | NS |
| Total | −4.9 (6) | 0.0001 | −0.4 (5) | NS | −0.4 (4) | NS | +0.1 (4) | NS | 0 | NS |
| Tender joints (28) | ||||||||||
| Women | −4.6 (7) | 0.0001 | −0.3 (5) | NS | 0 | NS | −0.4 (4) | NS | 0 | NS |
| Men | −4.5 (7) | 0.0001 | −0.6 (5) | NS | +1.1 (4) | 0.04 | +0.1 (5) | NS | +0.3 (5) | NS |
| Total | −4.6 (7) | 0.0001 | −0.4 (5) | −0.4 (5) | NS | −0.1 (4) | NS | +0.1 (4) | NS | |
| CRP (mg/l) | ||||||||||
| Women | −13.7 (25) | 0.0001 | −0.1 (16) | NS | +1.4 (19) | NS | −1.2 (16) | NS | +0.6 (17) | NS |
| Men | −11.4 (28) | 0.0001 | −0.7 (21) | NS | −2.3 (17) | NS | +0.1 (19) | NS | −0.7 (22) | NS |
| Total | −13 (26) | 0.0001 | −0.3 (18) | NS | +0.3 (18) | NS | −0.8 (17) | NS | 0 | NS |
| ESR (mm/1st h) | ||||||||||
| Women | −12.6 (21) | 0.0001 | 0 | NS | +0.1 (16) | NS | +0.4 (17) | NS | −1.4 (14) | NS |
| Men | −8.6 (20) | 0.0001 | −3.4 (18) | NS | −1.1 (12) | NS | +1.3 (15) | NS | +0.9 (12) | NS |
| Total | −13 (26) | 0.0001 | −0.3 (18) | NS | +0.3 (18) | NS | −0.8 (17) | NS | 0 | NS |
| Morning stiffness (min) | ||||||||||
| Women | −58 (82) | 0.0001 | +7.4 (59) | NS | +5.5 (69) | NS | −8.2 (58) | 0.05 | +4.1 (59) | NS |
| Men | −33 (74) | 0.0001 | −7.1 (70) | NS | −3.6 (61) | NS | −5.3 (55) | NS | +7.5 (59) | NS |
| Total | −50.6 (81) | 0.0001 | +2.7 (63) | NS | +2.6 (66) | NS | −7.3 (57) | 0.05 | +5 (59) | NS |
| PGA (0–1–2–3–4) | ||||||||||
| Women | −0.6 (1) | 0.0001 | −0.1 (1) | NS | −0.1 (1) | NS | −0.1 (1) | NS | 0 | NS |
| Men | −0.7 (1) | 0.0001 | −0.2 (1) | 0.03 | −0.2 (1) | 0.005 | +0.2 (1) | 0.04 | 0 | NS |
| Total | −0.6 (1) | 0.0001 | −0.11 (0.8) | 0.03 | −0.1 (0.9) | 0.04 | 0 | NS | 0 | NS |
| SOFI hand (0–16) | ||||||||||
| Women | −0.6 (2) | 0.0001 | −0.1 (2) | NS | +0.2 (2) | −0.1 (2) | NS | +0.2 (2) | NS | |
| Men | −0.8 (2) | 0.004 | +0.1 (2) | NS | −0.4 (2) | +0.5 (2) | 0.02 | 0 | NS | |
| Total | −0.7 (2) | 0.0001 | 0 | NS | 0 | +0.1 (2) | NS | +0.1 (2) | NS | |
| SOFI upper (0–12) | ||||||||||
| Women | −0.1 (1) | NS | 0 | NS | +0.1 (1) | NS | −0.1 (1) | NS | +0.1 (1) | NS |
| Men | −0.1 (2) | NS | −0.1 (2) | NS | 0 | NS | +0.1 (1) | NS | 0 | NS |
| Total | −0.1 (1) | NS | 0 | NS | +0.1 (1) | NS | 0 | NS | +0.1 (1) | NS |
| SOFI lower (0–16) | ||||||||||
| Women | −0.7 (2) | 0.0001 | 0 | NS | + 0.3 (2) | 0.02 | −0.1 (2) | NS | +0.3 (2) | NS |
| Men | −0.6 (2) | 0.002 | +0.3 (1) | NS | 0 | NS | +0.1 (2) | NS | −0.3 (2) | NS |
| Total | −0.6 (2) | 0.0001 | +0.1 (2) | NS | +0.2 (2) | NS | −0.1 (2) | NS | +0.1 (2) | NS |
| Walking time (s) | ||||||||||
| Women | −1.3 (4) | 0.0001 | +0.2 (3) | NS | +0.3 (3) | NS | −0.1 (2) | NS | +0.3 (2) | NS |
| Men | −1.3 (4) | 0.005 | +0.2 (2) | NS | 0 | NS | +0.4 (2) | NS | +2.2 (14) | NS |
| Total | −1.3 (4) | 0.0001 | +0.2 (3) | NS | +0.2 (3) | NS | +0.1 (2) | NS | +0.9 (8) | NS |
| Pain (mm VAS) | ||||||||||
| Women | −10.6 (30) | 0.0001 | 0 | NS | +3.8 (25) | 0.05 | −3.1 (25) | NS | −0.6 (25) | NS |
| Men | −15 (31) | 0.0001 | +0.5 (26) | NS | +0.1 (30) | NS | +0.1 (26) | NS | +1.5 (25) | NS |
| Total | −12 (30) | 0.0001 | +0.2 (26) | NS | +2.6 (27) | NS | −2.1 (25) | NS | 0 | NS |
| Wellbeing (mm VAS) | ||||||||||
| Women | −8.8 (31) | 0.0001 | +0.8 (26) | NS | +2.4 (27) | NS | −2.2 (26) | NS | +0.4 (25) | NS |
| Men | −3.8 (36) | NS | +2.6 (27) | NS | +0.3 (25) | NS | −1.6 (25) | NS | +3.4 (26) | NS |
| Total | −7.2 (33) | 0.0001 | −0.3 (26) | NS | +1.8 (26) | NS | −2 (26) | NS | +1.3 (25) | NS |