Table 1

Changes between follow ups

Months 0–3Months 3–6Months 6–12Months 12–18Months 18–24
Mean (SD)pMean (SD)pMean (SD)pMean (SD)pMean (SD)p
Swollen joints (28)
    Women−4.5 (6) 0.0001 −0.2 (4)NS−0.1 (4)NS−0.1 (5)NS−0.1 (4)NS
    Men−5.7 (6) 0.0001 −0.7 (5)NS−1.1 (5)NS+0.4 (4)NS+0.4 (5)NS
    Total−4.9 (6) 0.0001 −0.4 (5)NS−0.4 (4)NS+0.1 (4)NS0NS
Tender joints (28)
    Women−4.6 (7) 0.0001 −0.3 (5)NS0NS−0.4 (4)NS0NS
    Men−4.5 (7) 0.0001 −0.6 (5)NS+1.1 (4) 0.04 +0.1 (5)NS+0.3 (5)NS
    Total−4.6 (7) 0.0001 −0.4 (5)−0.4 (5)NS−0.1 (4)NS+0.1 (4)NS
CRP (mg/l)
    Women−13.7 (25) 0.0001 −0.1 (16)NS+1.4 (19)NS−1.2 (16)NS+0.6 (17)NS
    Men−11.4 (28) 0.0001 −0.7 (21)NS−2.3 (17)NS+0.1 (19)NS−0.7 (22)NS
    Total−13 (26) 0.0001 −0.3 (18)NS+0.3 (18)NS−0.8 (17)NS0NS
ESR (mm/1st h)
    Women−12.6 (21) 0.0001 0NS+0.1 (16)NS+0.4 (17)NS−1.4 (14)NS
    Men−8.6 (20) 0.0001 −3.4 (18)NS−1.1 (12)NS+1.3 (15)NS+0.9 (12)NS
    Total−13 (26) 0.0001 −0.3 (18)NS+0.3 (18)NS−0.8 (17)NS0NS
Morning stiffness (min)
    Women−58 (82) 0.0001 +7.4 (59)NS+5.5 (69)NS−8.2 (58) 0.05 +4.1 (59)NS
    Men−33 (74) 0.0001 −7.1 (70)NS−3.6 (61)NS−5.3 (55)NS+7.5 (59)NS
    Total−50.6 (81) 0.0001 +2.7 (63)NS+2.6 (66)NS−7.3 (57) 0.05 +5 (59)NS
PGA (0–1–2–3–4)
    Women−0.6 (1) 0.0001 −0.1 (1)NS−0.1 (1)NS−0.1 (1)NS0NS
    Men−0.7 (1) 0.0001 −0.2 (1) 0.03 −0.2 (1) 0.005 +0.2 (1) 0.04 0NS
    Total−0.6 (1) 0.0001 −0.11 (0.8) 0.03 −0.1 (0.9) 0.04 0NS0NS
SOFI hand (0–16)
    Women−0.6 (2) 0.0001 −0.1 (2)NS+0.2 (2)−0.1 (2)NS+0.2 (2)NS
    Men−0.8 (2) 0.004 +0.1 (2)NS−0.4 (2)+0.5 (2) 0.02 0NS
    Total−0.7 (2) 0.0001 0NS0+0.1 (2)NS+0.1 (2)NS
SOFI upper (0–12)
    Women−0.1 (1)NS0NS+0.1 (1)NS−0.1 (1)NS+0.1 (1)NS
    Men−0.1 (2)NS−0.1 (2)NS0NS+0.1 (1)NS0NS
    Total−0.1 (1)NS0NS+0.1 (1)NS0NS+0.1 (1)NS
SOFI lower (0–16)
    Women−0.7 (2) 0.0001 0NS+ 0.3 (2) 0.02 −0.1 (2)NS+0.3 (2)NS
    Men−0.6 (2) 0.002 +0.3 (1)NS0NS+0.1 (2)NS−0.3 (2)NS
    Total−0.6 (2) 0.0001 +0.1 (2)NS+0.2 (2)NS−0.1 (2)NS+0.1 (2)NS
Walking time (s)
    Women−1.3 (4) 0.0001 +0.2 (3)NS+0.3 (3)NS−0.1 (2)NS+0.3 (2)NS
    Men−1.3 (4) 0.005 +0.2 (2)NS0NS+0.4 (2)NS+2.2 (14)NS
    Total−1.3 (4) 0.0001 +0.2 (3)NS+0.2 (3)NS+0.1 (2)NS+0.9 (8)NS
Pain (mm VAS)
    Women−10.6 (30) 0.0001 0NS+3.8 (25) 0.05 −3.1 (25)NS−0.6 (25)NS
    Men−15 (31) 0.0001 +0.5 (26)NS+0.1 (30)NS+0.1 (26)NS+1.5 (25)NS
    Total−12 (30) 0.0001 +0.2 (26)NS+2.6 (27)NS−2.1 (25)NS0NS
Wellbeing (mm VAS)
    Women−8.8 (31) 0.0001 +0.8 (26)NS+2.4 (27)NS−2.2 (26)NS+0.4 (25)NS
    Men−3.8 (36)NS+2.6 (27)NS+0.3 (25)NS−1.6 (25)NS+3.4 (26)NS
    Total−7.2 (33) 0.0001 −0.3 (26)NS+1.8 (26)NS−2 (26)NS+1.3 (25)NS