Variation in Sharp score values (mean and range) between baseline and three and five years in patients with rheumatoid arthritis with or without anticitrullinated protein/peptide autoantibodies. Results are shown as mean (range)
| Progression 0–3 years | Progression 0–5 years | |||||
|---|---|---|---|---|---|---|
| Baseline status | Total | Erosions | Joint space narrowing | Total | Erosions | Joint space narrowing |
| CCP, cyclic citrullinated peptides; APF, antiperinuclear factor; AKA, antikeratin antibody. | ||||||
| Anti-CCP+ | 11.98 (0–72) | 6.11 (0–46) | 5.85 (0–48) | 16.46 (0–89) | 6.04 (0–28) | 10.43 (0–67) |
| Anti-CCP− | 7.32 (0–55) | 3.44 (0–30) | 3.87 (0–33.5) | 8.60 (0–77) | 3.41 (0–46) | 5.19 (0–36) |
| p | 0.0006 | 0.0004 | 0.032 | 0.002 | <0.0001 | 0.0049 |
| APF + | 9.34 (0–58) | 4.6 (0–38) | 4.74 (0–44) | 17.15 (0–89) | 6.06 (0–28) | 11.09 (0–67) |
| APF − | 5.08 (0–39) | 3.19 (0–29) | 1.72 (0–18) | 9.68 (0–77) | 4.02 (0–46) | 5.65 (0–53) |
| p | 0.009 | 0.058 | 0.009 | 0.0072 | 0.0089 | 0.0011 |
| AKA + | 7.81 (0–57) | 3.96 (0–38) | 3.72 (0–22) | 14.0 (0–73) | 4.74 (0–28) | 9.25 (0–62) |
| AKA − | 6.86 (0–58) | 3.85 (0–22) | 2.93 (0–44) | 12.78 (0–89) | 5.13 (0–46) | 7.64 (0–67) |
| p | 0.22 | 0.17 | 0.50 | 0.21 | 0.37 | 0.19 |