Publications on high dose and low dose MTX osteopathy since the first report in 1970
| High dose | Low dose |
|---|---|
| Cumulative dose: 7.5–144 g/m2 | Cumulative dose: 97.5 mg–3.5 g |
| Onset: 4–11 months | Onset: 3 months–8.5 years |
| Ragab et al, 1970 | Preston SJ et al, 1993 |
| Newman et al, 1973 | Shapira D et al, 1995 |
| O’Regan et al, 1973 | Maenaut et al, 1996 |
| Koller et al, 1976 | Zonneveld et al, 1996 |
| Stanisavljevic et al, 1977 | Bologna et al, 1996 |
| Jaffe et al, 1987 | Singwe M et al, 1998 |
| Vassilopoulou-Sellin et al, 1992 | Stevens et al, 2001 |
| Meister et al, 1994 | Wijnands et al, 2001 |
| Exclund et al, 1997 | Rudler et al, 2003 |
| Warner et al, 1999 |