Performance of three anticitrullinated protein/peptide tests and of rheumatoid factor in predicting progression of the total, erosion, and joint space narrowing Sharp scores
| Antibody positive at baseline | 5 Year Sharp score | OR (95% CI) | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|
| OR, odds ratio; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; CCP, cyclic citrullinated peptides; APF, antiperinuclear factor; AKA, antikeratin antibody; RF, rheumatoid factor. | ||||||
| Anti-CCP | Total | 2.5 (1.2 to 5.0) | 67 | 57 | 64 | 58 |
| Erosions | 3.4 (1.6 to 7.2) | 74 | 54 | 49 | 77 | |
| Narrowing | 1.8 (0.8 to 3.6) | 62 | 51 | 56 | 58 | |
| APF | Total | 2.4 (1.2 to 4.9) | 57 | 64 | 66 | 64 |
| Erosions | 1.3 (0.6 to 2.7) | 52 | 55 | 35 | 71 | |
| Narrowing | 2.4 (1.2 to 4.7) | 58 | 63 | 60 | 61 | |
| AKA | Total | 1.3 (0.6 to 2.6) | 38 | 68 | 57 | 50 |
| Erosions | 1.2 (0.5 to 2.5) | 32 | 64 | 29 | 67 | |
| Narrowing | 1.4 (0.7 to 2.8) | 39 | 69 | 55 | 54 | |
| RF | Total | 0.7 (0.3 to 1.5) | 69 | 24 | 47 | 45 |
| Erosions | 1.2 (0.5 to 2.8) | 69 | 26 | 27 | 67 | |
| Narrowing | 0.5 (0.2 to 1.1) | 65 | 22 | 40 | 45 | |