Table 4

Comparison of improvement criteria sets that best represented the consensus of the experts and ASAS-IC with the end of trial efficacy assessment by the doctor and the patient

Improvement definition% Agreement compared with efficacy assessment (n=473)*SensitivitySpecificity
VAS, visual analogue scale; ASAS-IC, Assessment in Ankylosing Spondylitis improvement criteria.
*Ten patients were omitted from this analysis, because of a disagreement between the patient and the doctor end of trial efficacy assessment. Another 27 patients were omitted from this analysis because of missing data on domains of the ASAS-IC.
Sensitivity (proportion of responders correctly classified) and specificity (proportion of non-responders correctly classified) were calculated considering the end of trial efficacy assessment as the “gold standard”.
Relative improvement
    30% in 2 of 4777384
    20% in 3 of 4776788
    20% in 2 of 4828381
    10% in 3 of 4807984
Combinations in relative improvement
    40% in 2 of 4 or 20% in 3 of 4767285
    30% in 2 of 4 or 20% in 3 of 4777583
Relative and absolute improvement
    30% and 10 VAS in 2 of 4767285
    20% and 10 VAS in 2 of 4818083
Combinations in relative and absolute improvement
    40% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 4757186
    30% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 4777484
Relative improvement including pain
    30% in 2 of 4, including pain767286
    20% in 3 of 4, including pain736688
    20% in 2 of 4, including pain818084
Combinations in relative improvement including pain
    40% in 2 of 4 or 20% in 3 of 4, all including pain767188
    30% in 2 of 4 or 20% in 3 of 4, all including pain777385
Relative and absolute improvement including pain
    30% and 10 VAS in 2 of 4, all including pain757186
    20% and 10 VAS in 2 of 4, all including pain807884
Combinations in relative and absolute improvement including pain
    40% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 4, all including pain757088
    30% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 4, all including pain767285
ASAS Improvement Criteria (ASAS-IC)
    20% and 10 VAS in 3 of 4, 4th no worsening of ⩾20% and 10 VAS706289