Table 3

Improvement criteria sets showing ⩾80% agreement with the consensus of the experts and tested for their discriminative performances between placebo and actively treated patients

Validation subset
Improvement definition% Agreement compared with consensus of the experts (n=55)% Responders in placebo treated group (n=197)% Responders in active treated group (n=408)Differenceχ2 Value
VAS, visual analogue scale; ASAS-IC, Assessment in Ankylosing Spondylitis improvement criteria.
All χ2 values showed p values of <0.001
Relative improvement
    30% in 2 of 48233602740
    20% in 3 of 48427552841
    20% in 2 of 49142692742
    10% in 3 of 49136622638
Combinations in relative improvement
    40% in 2 of 4 or 20% in 3 of 48930582844
    30% in 2 of 4 or 20% in 3 of 49334622842
Relative and absolute improvement
    30% and 10 VAS in 2 of 48033602739
    20% and 10 VAS in 2 of 49340672742
Combinations in relative and absolute improvement
    40% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 48729582944
    30% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 49133612843
Relative improvement including pain
    30% in 2 of 4, including pain8229562738
    20% in 3 of 4, including pain8026532741
    20% in 2 of 4, including pain9337642740
Combinations in relative improvement including pain
    40% in 2 of 4 or 20% in 3 of 4, all including pain8727562943
    30% in 2 of 4 or 20% in 3 of 4, all including pain9130592943
Relative and absolute improvement including pain
    30% and 10 VAS in 2 of 4, all including pain8029562739
    20% and 10 VAS in 2 of 4, all including pain9335632842
Combinations in relative and absolute improvement including pain
    40% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 4, all including pain8527552843
    30% in 2 of 4 or 20% in 3 of 4 and 10 VAS in 2 of 4, all including pain8930592945
ASAS Improvement Criteria (ASAS-IC)
    20% and 10 VAS in 3 of 4, 4th no worsening of ⩾20% and 10 VAS6225512636