Comparison of the clinical and laboratory variables of normouricaemic gout and hyperuricaemic gout at diagnosis
| Normouricaemic gout (n=27) | Hyperuricaemic gout (n=81)* | p Value | |
|---|---|---|---|
| BMI, body mass index; MTP, metatarsophalangeal joint; NS, not significant; BUN, blood urea nitrogen. | |||
| *Patients with hyperuricaemia were randomly selected from the study group using a table of random sampling; †renal insufficiency was defined as a serum creatinine level above 130 μmol/l or a creatinine clearance below 1.00 ml/s; ‡precipitating events for an acute attack of gout are binge drinking, meat, surgery, infection, trauma, physical stress, and deterioration of underlying medical disease; §associated diseases are acute renal failure, chronic renal failure, renal transplantation, coronary artery occlusion disease, heart failure, stroke, and pulmonary tuberculosis; ¶polyarticular involvement was defined as more than one joint affected in a gouty attack. | |||
| Demographics | |||
| Age (years) | 60.6 (13.9) | 54.2 (11.8) | 0.02 |
| First symptom to diagnosis (months) | 32.2 (36.3) | 54.2 (66.3) | 0.03 |
| BMI (kg/m2) | 23.8 (2.9) | 23.1 (3.3) | NS |
| Associated conditions | |||
| Hypertension | 15 | 40 | NS |
| Renal insufficiency† | 5 | 28 | NS |
| Heavy alcoholic intake | 5 | 9 | NS |
| Diabetes mellitus | 2 | 11 | NS |
| Precipitating events‡ | 11 | 35 | NS |
| Associated diseases§ | 12 | 30 | NS |
| Articular involvement | |||
| First MTP | 19 | 57 | NS |
| Upper extremities | 1 | 15 | NS |
| Lower extremities | 27 | 76 | NS |
| Polyarticular involvement¶ | 11 | 45 | NS |
| Documented tophi | 4 | 36 | 0.006 |
| Serum uric acid (μmol/l) | 320 (80) | 550 (90) | <0.001 |
| 24 Hour urinary uric acid excretion (mmol/day) | 4 (1) | 4 (5) | NS |
| BUN (mmol/l) | 5.5 (2.0) | 7.5 (1.5) | 0.02 |
| Creatinine (μmol/l) | 100 (30) | 140 (110) | 0.002 |