Table 2

Objective changes of ocular features in the patients with Sjögren’s syndrome

VariablesPilocarpineArtificial tearsLachrymal puncta occlusion
BaselineDifferenceBaselineDifferenceBaselineDifference
Results are shown as mean (SD).
RE, right eye; LE, left eye; C/N, cytoplasm/nucleus ratio of epithelial cells.
*p<0.05 in favour of pilocarpine in comparison with other treated groups.
Schirmer-I (<5 mm/5 min)
    RE4.5 (2.2)0.3 (1.1)5.1 (1.0)0.2 (0.8)5.0 (1.0)0.2 (0.4)
    LE4.4 (1.9)1.2 (1.3)4.3 (1.2)0.6 (0.9)4.5 (0.9)0.7 (0.8)
Rose bengal (<4 Bijsterveld’s score)
    RE4.6 (1.9)−1 (1.3)*4.2 (2.0)0.0 (0.5)4.6 (2.3)−0.9 (1.2)
    LE4.7 (2.2)−1.1 (1.0)*4.2 (1.9)0.0 (0.7)4.5 (1.9)−0.5 (0.9)
C/N ratio (3–4:1)
    RE4.0 (0.9)−0.1 (1.3)3.7 (1.0)0.0 (1.0)3.6 (0.8)0.2 (0.9)
    LE4.0 (1.1)−0.1 (1.2)3.6 (0.8)0.1 (0.9)3.5 (0.8)0.1 (0.8)
Goblet cells (n) 100–300/mm2
    RE53.1 (42.7)46.6 (187.2)90.5 (164.0)−43.5 (181.9)92.4 (173.6)2.5 (188.5)
    LE74.9 (68.7)6.2 (133.9)65.9 (116.8)−23.3 (131.3)64.6 (125.5)18.2 (131.7)