Table 3

Clinical characteristics and outcomes of 15 patients with catastrophic APS who developed further APS related events

NoSexAgeDiseaseCatastrophic manifestationsAnticoagulationAPS related thrombosisTriggerOutcome
F, female; M, male; SLE, systemic lupus erythematosus; PAPS, primary antiphospholipid syndrome; a, artery; v, vein; ASA, aspirin; War (target INR), warfarin; LMWH, low molecular weight heparin.
*Worsening renal failure followed by retroperitoneal bleeding secondary to renal artery aneurysm.
1F33SLEHepatic, renal, portal vein, skinASAArterial-venous graftSurgeryRecovery
2F25PAPSHepatic, renal, splenic, bone, marrow, nose, skinWar (3–4)CardiacSurgeryDeath
3M37PAPSHepatic, renal, pancreatic, pulmonaryWar (3–4)Aortoiliac junctionNoRecovery
4F33PAPSRenal, pulmonary, cerebral,WarPulmonaryNoDeath
5M22PAPSPeripheral (v and a), prostateWarPenile arteryLow INRRecovery
6F30SLEHepatic, renal, cerebral, boneASARenal artery graftSurgeryRecovery
7M47PAPSPeripheral (a), renal, cerebral, cardiac, pulmonary, skinWarPulmonaryNoRecovery
8M52PAPSPeripheral (a), renal, cerebral, cardiac, pulmonary, skinWar (2–3)CerebralNoRecovery
9F17SLEPeripheral (v), renal, cerebral, pulmonary, skinWarPeripheral (v), pulmonaryNoRecovery
10F51SLERenal, splenic, pancreatic, cardiacWar (>3)CardiacNoRecovery
11F25PAPSHepatic, renal, cardiacWar/ASAArterial-venous graftSurgeryRecovery
12F23PAPSPeripheral (v), pulmonary, retinalWar (2–2.5)PulmonaryNoRecovery
13F49PAPSPeripheral (v), hepatic, cardiacWar (3–4)Peripheral (a)SurgeryRecovery
14M30PAPSCerebral, adrenalLMWHPulmonaryNoDeath
15M62PAPSRenal, cardiac, cerebralWar (3–4)Renal*SurgeryDeath