Extra-articular manifestations (EAMs) of recent onset in 81 patients suspected of rheumatoid vasculitis and associations between EAMs and histologically proven rheumatoid vasculitis. Results are shown as No (%)
| HRV (n=31) | RA+EAM (n=50) | Odds ratio* (95% confidence interval) | |
|---|---|---|---|
| HRV, histologically proven rheumatoid vasculitis and recent onset of extra-articular manifestations; RA+EAM, rheumatoid arthritis with recent onset of extra-articular manifestations, but without histological evidence of vasculitis; DSSN, distal symmetric sensory or sensorimotor neuropathy. | |||
| *Association of EAM with RV; | |||
| †number of patients (%); | |||
| Peripheral neuropathy | 14 (45)† | 6 (12) | 6.04 (1.9 to 18.9) |
| Mononeuritis multiplex | 3 (10) | – | ∞ |
| DSSN | 14 (45) | 6 (12) | 6.04 (1.9 to 18.9) |
| Skin | 25 (81) | 29 (58) | 3.02 (1.0 to 8.8) |
| Ulcers | 7 (23) | 11 (22) | 1.03 (0.3 to 3.1) |
| Deep skin ulcer | 3 (10) | 2 (4) | 2.56 (0.4 to 16.8) |
| Superficial skin ulcer | 4 (13) | 9 (18) | 0.68 (0.2 to 2.5) |
| Gangrene | 1 (3) | 1 (2) | 1.63 (0.1 to 28.5) |
| Purpura/petechiae | 14 (45) | 3 (6) | 12.94 (3.2 to 52.5) |
| Nailfold lesions | 14 (45) | 21 (42) | 1.14 (0.5 to 2.9) |
| Systemic features (weight loss+ fever) | 14 (45) | 24 (48) | 1.65 (0.2 to 12.9) |
| Weight loss | 13 (42) | 19 (38) | 1.17 (0.5 to 3.0) |
| Fever | 3 (10) | 7 (14) | 0.66 (0.2 to 2.8) |
| Eye involvement | 5 (16) | 4 (8) | 2.21 (0.5 to 9.2) |
| Scleromalacia perforans | 1 (3) | 1 (2) | 1.63 (0.19 to 28.5) |
| (Epi-)scleritis | 4 (13) | 3 (6) | 2.32 (0.5 to 11.5) |
| Pericarditis | 0 | 1 (2) | 0 (–) |
| Pleuritis | 2 (6) | 6 (12) | 0.51 (0.1 to 2.3) |
| Fibrosing alveolitis | 1 (3) | 1 (2) | 1.63 (0.1 to 28.5) |
| Multiple rheumatoid nodules (recent onset) | 2 (6) | 4 (8) | 0.79 (0.1 to 4.8) |