Table 3

Influence of methotrexate treatment on leptin levels. Results are shown as mean (SEM) unless otherwise stated

Treated with MTX (n=28)Treated with other DMARD (n=17)Non-treated (n=31)
*p=0.003 DMARD treated versus non-treated;
†p=0.002 MTX treated versus other DMARD treated;
‡p=0.024 plasma versus synovial fluid, non-treated group.
Disease duration (years)13.9 (1.7)8.8 (1.6)11.5 (1.8)
Erosive disease (No (%))23 (82)11 (65)15 (48)
Oral glucocorticoids (No (%))11 (39)6 (35)7 (22)
C reactive protein (mg/l)46.3 (6.9)49.8 (16.8)36.0 (8.9)
Folic acid (nmol/l)28.5 (4.9)33.5 (9.5)*14.2 (3.1)
Leptin levels (ng/ml)
    Plasma5.9 (1.2)†3.4 (0.3)6.8 (1.2)‡
    Synovial fluid5.1 (1.0)3.5 (1.3)5.1 (0.9)