Median doses (and quartiles) of methotrexate (MTX) and sulfasalazine (SSZ) over the years (42 month periods)*
| MTX (mg/week) | SSZ (g/day) | |
|---|---|---|
| *Kruskal-Wallis-test: p<0.001 for dose changes over time periods for both MTX and SSZ. Median doses of the total cohort: MTX 12.5 mg/week (10; 15); SSZ 2.0 g/day (1.5; 3.0). | ||
| (1) Jul 1988–Dec 1991 | 10 (7.5; 10) | 1.5 (1.0; 3.0) |
| (2) Jan 1992–Jun 1995 | 10 (7.5; 12.5) | 2.0 (1.5; 2.0) |
| (3) Jul 1995–Dec 1998 | 12.5 (10; 15) | 2.0 (1.5; 3.0) |
| (4) Jan 1999–Jun 2002 | 15 (10; 20) | 2.0 (2.0; 3.0) |