Clinical characteristics of patients with lcSSc receiving minocycline for calcinosis and response to treatment
| Patient | Age (years) | Sex | Disease duration (years) | Clinical features | Autoantibodies | Date starting minocycline | Improvement |
|---|---|---|---|---|---|---|---|
| 1 | 55 | F | 17 | Raynaud’s . . . . . .Calcinosis | Anticentromere +ve | Nov 1994 | Within 1 month |
| Telangiectasia . . . . . .Arthritis | |||||||
| Oesophageal | |||||||
| 2 | 85 | F | 27 | Sclerodactyly . . . . . .Calcinosis | ANA +ve | Jun 1996 | Over 1 year |
| Arthritis | 1/320 | ||||||
| 3 | 74 | F | 5 | Raynaud’s . . . . . .Calcinosis | Anticentromere +ve | Apr 1996 | Within 5 months |
| Telangiectasia . . . . . .Sclerodactyly | |||||||
| Oesophageal . . . . . .Arthritis | |||||||
| 4 | 72 | F | 17 | Raynaud’s . . . . . .Calcinosis | Negative | Sep 1999 | Within 7 months |
| Telangiectasia . . . . . .Sclerodactyly | |||||||
| Oesophageal | |||||||
| 5 | 58 | F | 15 | Raynaud’s . . . . . .Calcinosis | ANA +ve | Nov 1999 | Over 1 year |
| Pulmonary fibrosis | 1/160 | ||||||
| Sclerodactyly | |||||||
| 6 | 70 | F | 1 | Raynaud’s . . . . . .Calcinosis | ANA +ve | Apr 2000 | Within 5 months |
| Telangiectasia . . . . . .Sclerodactyly | 1/640 | ||||||
| 7 | 70 | F | 1.5 | Raynaud’s . . . . . .Calcinosis | Anticentromere +ve | Feb 2000 | Within 6 months. Died of oesophageal carcinoma June 2001 |
| Telangiectasia . . . . . .Sclerodactyly | |||||||
| 8 | 74 | F | 8 | Raynaud’s . . . . . .Calcinosis | Anticentromere +ve | Aug 1992 | Minimal – poorly tolerated |
| Telangiectasia . . . . . .Sclerodactyly | |||||||
| 9 | 38 | F | 16 | Raynaud’s . . . . . .Calcinosis | Anticentromere +ve | May 1995 | Within 1 month |
| Telangiectasia . . . . . .Sclerodactyly | |||||||
| Oesophageal |