Vectors commonly used for salivary gland gene transfer
| Vector | Advantage | Disadvantage |
|---|---|---|
| AAV, adeno-associated virus. | ||
| Adenovirus | Highly efficient transduction | Short term expression of the transgene (weeks) |
| Relatively simple production | Potent immune response possible | |
| Transduces non-dividing cells | ||
| Large gene packaging capacity | ||
| AAV | Efficient transduction | Limited packaging capacity (max 4.6 kb) |
| Transduces non-dividing cells | Difficult to produce | |
| Long term expression (months/years) | ||
| Modest immune response | ||
| Non-viral | Simple to produce | Low transduction efficiency |
| Low immune response | Relatively short term expression (days) | |
| Inexpensive | ||