Autoradiography slides; total grain volume fraction (% of the total tissue volume occupied by grains) in superficial, middle, and deep cartilage layers
| Young rabbits | Old rabbits | |||||
|---|---|---|---|---|---|---|
| Group | Superficial zone | Intermediate zone | Deep zone | Superficial zone | Intermediate zone | Deep zone |
| *Mean (SEM); †mean values of negative controls. | ||||||
| Data represent the mean (SEM) (with number of paired observations in parentheses at the head of the column). The two tailed non-parametric Wilcoxon’s matched pairs signed ranks test was used for statistical analysis; no significant differences were found between the synovectomy and control groups. | ||||||
| (n=8) | Four days after [166Ho]FHMA | (n=6) | ||||
| Synovectomy | 3.174 (0.994)* | 3.059 (0.625) | 2.931 (0.612) | 1.468 (0.391) | 1.429 (0.373) | 1.111 (0.248) |
| Control | 2.317 (0.457) | 3.270 (0.81) | 2.920 (0.628) | 0.747 (0.123) | 0.825 (0.200) | 0.838 (0.259) |
| Normal controls | 5.748† | 6.448 | 5.844 | 1.614 | 1.767 | 1.456 |
| (n=9) | Two months after [166Ho]FHMA | (n=7) | ||||
| Synovectomy | 2.318 (0.537) | 2.274 (0.389) | 1.968 (0.302) | 1.248 (0.159) | 1.479 (0.144) | 1.220 (0.102) |
| Control | 1.568 (0.265) | 1.737 (0.259) | 1.591 (0.242) | 1.907 (0.356) | 1.740 (0.305) | 1.306 (0.182) |
| Normal controls | 4.66 | 4.604 | 3.829 | 1.614 | 1.767 | 1.456 |
| (n=9) | One year after [166Ho]FHMA | (n=6) | ||||
| Synovectomy | 3.442 (0.249) | 3.649 (0.164) | 3.577 (0.133) | 3.230 (0.227) | 3.261 (0.253) | 3.215 (0.286) |
| Control | 3.883 (0.860) | 4.539 (1.172) | 4.690 (1.370) | 3.493 (0.253) | 3.787 (0.349) | 3.265 (0.277) |
| Normal controls | 3.529 | 3.482 | 2.790 | 5.022 | 5.258 | 4.639 |