Area integrated optical retardation (AIR) of polarised light due to collagen network in the normal looking superficial, intermediate, and deep zones of the medial tibial cartilage condyles, thickness of the corresponding cartilage zones, thickness of the subchondral bone plate, AIR, and volume fraction (Vv) of the bone in the subchondral bone plate
| Non-transgenic non-runners | Non-transgenic runners | Transgenic non-runners | Transgenic runners | |||||
|---|---|---|---|---|---|---|---|---|
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Articular cartilage | ||||||||
| AIR superficial zone (1/μm2) | 4.64×10−4 | 5.17×10−5 | 4.82×10−4 | 5.34×10−5 | 5.31×10−4 | 2.53×10−5 | 4.71×10−4 | 2.27×10−5 |
| AIR, Intermediate zone (1/μm2) | 3.29×10−4 | 1.27×10−5 | 3.53×10−4 | 3.29×10−5 | 3.85×10−4 | 4.36×10−5 | 3.27×10−4 | 1.28×10−5 |
| AIR, deep zone (1/μm2) | 3.99×10−4 | 2.96×10−5 | 5.17×10−4 | 6.64×10−5 | 4.30×10−4 | 5.73×10−5 | 4.14×10−4 | 2.53×10−5 |
| Thickness, superficial zone (μm) | 15.6 | 2.8 | 10.1 | 2.2 | 12.3 | 3.0 | 7.8 | 2.7 |
| Thickness, intermediate zone (μm) | 9.8 | 0.8 | 9.7 | 1.4 | 7.0 | 1.5 | 4.5 | 1.6 |
| Thickness, deep zone (μm) | 75.2 | 6.7 | 98.1 | 9.2 | 64.1 | 11.6 | 70.2 | 8.4 |
| Subchondral bone | ||||||||
| Thickness, subchondral bone (μm) | 400.9 | 37.5 | 402.5 | 23.2 | 428.6 | 41.5 | 461.7 | 31.9 |
| AIR, subchondral bone (1/μm2) | 1.43×10−3 | 3.91×10−5 | 1.42×10−3 | 1.31×10−4 | 1.42×10−3 | 9.26×10−5 | 1.39×10−3 | 6.09×10−5 |
| Vv, subchondral bone (%) | 0.44 | 0.06 | 0.47 | 0.07 | 0.45 | 0.08 | 0.39 | 0.06 |