Table 1

Patient characteristics and reasons for withdrawal of 13 participants with OA of the hip or knee in a series of n of 1 trials

Patient NoSex (M/F), age, jointDrug treatment before the start of the trialTrial drugNumber of weeks completed, reasons for withdrawal
*The patient received 2000 mg instead of 3000 mg paracetamol daily because of alcohol use (about six units a day).
1F, 71, hip3×day 400 mg ibuprofen3×day 400 mg ibuprofen v 3×day 1000 mg paracetamol20
2M, 82, knee3×day 50 mg diclofenac2×day 50 mg diclofenac v 3×day 1000 mg paracetamol0, (only 3 days): Perceived lack of efficacy (stiffness)
3F, 80, knee3 (sometimes 4) ×day 400 mg ibuprofen3×day 400 mg ibuprofen v 3×day 1000 mg paracetamol20
4F, 91, kneeMostly 1×day 50 mg diclofenac (sometimes more)1×day 50 mg diclofenac v 1×day 1000 mg paracetamol and 1×day 500 mg paracetamol20
5M, 50, knee1×day 50 mg diclofenac1×day 50 mg diclofenac v 1×day 1000 mg paracetamol and 1×day 500 mg paracetamol20
6F, 54, knee1 or 2×day 500 mg naproxen1×day 250 mg naproxen and 1×day 500 mg naproxen v 3×day 1000 mg paracetamol20
7F, 73, knee1×day 50 mg diclofenac1×day 50 mg diclofenac v 1×day 1000 mg paracetamol and 1×day 500 mg paracetamol. After 2 weeks she was prescribed 1000 mg additional paracetamol because of concomitant disease (gout)20
8F, 62, knee1 or 2×day 100 mg diclofenac2×day 50 mg diclofenac v 2×day 1000 mg paracetamol*4: Perceived lack of efficacy (pain)
9F, 82, knee1×day 75 mg diclofenac and 500 mg paracetamol1×day 25 mg diclofenac and 1×day 50 mg diclofenac v 3×day 1000 mg paracetamol (after 4 weeks 2×day 1000 mg paracetamol)20
10F, 72, knee1×day 50 mg diclofenac, sometimes 2×day 50 mg diclofenac1×day 50 mg diclofenac v 1×day 1000 mg paracetamol and 1×day 500 mg paracetamol8: Concomitant disease (back pain) and loss of motivation
11F, 77, knee3×day 50 mg diclofenac2×day 50 mg diclofenac v 3×day 1000 mg paracetamol4: Perceived side effects stomach complaints and nausea)
12F, 79, knee3×day 50 mg diclofenac2×day 50 mg diclofenac v 3×day 1000 mg paracetamol4: Perceived lack of efficacy (pain)
13F, 90, knee3×day 400 mg ibuprofen (and almost every day 500 mg paracetamol/codeine, sometimes also 1×day 500 g paracetamol)3×day 400 mg ibuprofen v 3×day 1000 mg paracetamol2: Perceived lack of efficacy (pain)