Table 7

Research agenda based on expert opinion

1Clinical predictors of response to pharmacological and non-pharmacological interventions need to be determined
2There is a need to establish a set of recommendations for uniform and full reporting of clinical trials in knee OA
3Studies should include quality of life and function as well as pain, as outcome measures
4New imagining techniques—that is, MRI and ultrasound require validation for the diagnosis and follow up of knee OA
5Randomised controlled trials should more fully assess non-pharmacological interventions for knee OA
6The most efficient and effective exercises need to be determined
7What is the effect on tissue, efficacy, and safety of long term COX 2 inhibition
8The clinical relevance of structural modification requires evaluation
9The indications for joint replacement need to be determined
10There is a need to examine the efficacy and cost utility of surgical techniques