Table 1

Conventional systolic and diastolic blood pressure measurements, 24 hour averages of blood pressure, and heart frequency before (initial ABPM) and after treatment with leflunomide (final ABPM) in 17 patients with rheumatoid arthritis. Twenty four hour, day time (6 00 am to 10 00 pm), and night time (10 00 pm to 6 00 am) mean values and standard deviations are shown. Statistical significance of differences was tested with Student's t test. p Values of ≤0.05 were considered significant

Initial measurementFinal measurementt TestSignificance (p)
Conventional measurements (mean)
    Systolic blood pressure (mm Hg)127.3 (20.2)140.7 (20.1)3.550.003
    Diastolic blood pressure (mm Hg)76.7 (9.3)84.0 (8.6)3.080.007
ABPM (mean)
    Systolic blood pressure (mm Hg)127.8 (19.7)132.1 (21.4)3.010.003
    Diastolic blood pressure (mm Hg)74.9 (12.4)79.7 (13.0)5.430.000
    Mean arterial pressure (mm Hg)93.6 (14.8)98.7 (15.8)4.760.000
    Pulse pressure (mm Hg)52.9 (14.0)52.4 (15.5)0.46NS
    Heart frequency (min−1)77.6 (13.7)80.2 (13.5)2.710.007
Day time (6 00 am to 10 00 pm)
    Systolic blood pressure (mm Hg)130.2 (18.2)135.2 (19.6)5.180.000
    Diastolic blood pressure (mm Hg)77.8 (11.4)83.1 (11.7)9.040.000
    Mean arterial pressure (mm Hg)96.1 (13.4)83.1 (11.7)7.860.000
    Pulse pressure (mm Hg)52.5 (14.2)52.1 (15.4)0.44NS
    Heart frequency (min−1)81.8 (13.7)83.7 (13.3)2.830.005
Night time (10 00 pm to 6 00 am)
    Systolic blood pressure (mm Hg)121.9 (20.6)124.1 (20.6)1.20NS
    Diastolic blood pressure (mm Hg)69.1 (12.2)72.3 (11.8)3.070.002
    Mean arterial pressure (mm Hg)87.8 (15.5)91.5 (14.6)2.770.006
    Pulse pressure (mm Hg)52.8 (13.3)51.7 (15.0)0.86NS
    Heart frequency (min−1)68.7 (9.2)72.9 (10.9)4.780.000