Specific outcome of 13 pregnancies in seven women with anti-SSA/Ro antibodies who had previously had fetuses with CHB
| Patient No | Current maternal diagnosis | Previous pregnancies with CHB | Corticosteroid treatment of following pregnancies | Outcome of following pregnancies | Sex | Gestational age (WG) | Birth weight (g) |
|---|---|---|---|---|---|---|---|
| *Intrauterine growth restriction (birth weight lower than the third centile for gestational age). | |||||||
| CHB, congenital heart block; WG, weeks’ gestation; SLE, systemic lupus erythematosus; primary SS, primary Sjögren’s syndrome; APL, antiphospholipid antibodies. | |||||||
| 1 | SLE | 1 CHB (death at 2 days of life) | Dexamethasone (4 mg/day) | Spontaneous abortion (15 WG) | – | – | – |
| Prednisone (10 mg/day) | Live birth | F | 40 | 4130 | |||
| 2 | SLE | 1 CHB (death at 6 months of life) | Dexamethasone (4.5 mg/day) | Spontaneous abortion (18 WG) | – | – | – |
| Dexamethasone (4.5 mg/day) | Stillbirth (24 WG) | – | – | – | |||
| Prednisone (10 mg/day) | Live birth | F | 38 | 2680 | |||
| 3 | Primary SS | 2 CHB (pacemaker in both cases) | Dexamethasone (4 mg/day) | Live birth (adrenal insufficiency) | M | 37 | 2140* |
| Dexamethasone (4 mg/day) | Live birth (adrenal insufficiency) | M | 37 | 1870* | |||
| 4 | Symptom free | 1 CHB (stillbirth at 30 WG) | None | Spontaneous abortion (11 WG) | – | – | – |
| None | Live birth | F | 40 | 4030 | |||
| 5 | Primary SS | 1 CHB (no need of pacemaker at 4 years) | Dexamethasone (5 mg/day) | Stillbirth (32 WG) (adrenal hypoplasia) | – | – | – |
| 6 | Primary SS | 1 CHB (no need of pacemaker at 10 years) | Prednisone (10 mg/day) | Live birth | F | 39 | 2930 |
| 7 | Primary SS + high APL | 1 CHB (pacemaker at 18 months) | None | Spontaneous abortion (5 WG) | – | – | – |
| Prednisone (10 mg/day) | Live birth | M | 39 | 3080 | |||