Global, peripheral, and axial assessments at baseline, and at weeks 12, 20, 22, 34, 36, 48, and 50
| Baseline | Week 12 | Week 20 | Week 22 | Week 34 | Week 36 | Week 48 | Week 50 | |
|---|---|---|---|---|---|---|---|---|
| Values are given as median (range). *p≤0.05, **p≤0.01, ***p≤0.001, NS, not significant (determined by Wilcoxon signed ranks test compared with baseline). | ||||||||
| Global assessment | (n=21) | (n=21) | (n=19) | (n=19) | (n=19) | (n=18) | (n=19) | (n=19) |
| Patient global (0–100) | 57 (27–100) | 10 (1–73)*** | 10 (0–94)*** | 6 (0–34)*** | 24 (1–97)*** | 5.5 (0–41)*** | 22 (2–95)* | 14 (2–47)*** |
| Patient pain (0–100) | 70 (23–100) | 10 (1–86)*** | 14 (1–96)*** | 8 (1–37)*** | 29 (1–100)*** | 7.5 (1–37)*** | 26 (2–100)* | 15 (1–60)*** |
| Doctor global (0–100) | 57 (12–79) | 10 (5–75)*** | 14 (1–38)*** | 14 (1–32)*** | 20 (1–60)** | 10 (5–23)*** | 21 (7–73)* | 12 (4–20)*** |
| ESR (mm/1st h) | 44 (10–101) | 4 (2–68)*** | 7 (2–30)*** | 5 (2–15)*** | 17 (1–91)** | 5 (1–25)*** | 26 (1–97) NS | 6 (1–28)*** |
| CRP (mg/l) | 46 (7–290) | 6 (0–155)*** | 6 (0–64)*** | 3 (0–9)*** | 22 (0–204)** | 2.8 (0–15.5)*** | 25.7 (0–253.7) NS | 3.7 (0–26.7)*** |
| Peripheral assessment | (n=18) | (n=18) | (n=16) | (n=16) | (n=16) | (n=15) | (n=16) | (n=16) |
| Morning stiffness (min) | 90 (10–300) | 5 (0–60)*** | 10 (0–300)** | – | 25 (0–120)* | – | 25 (0–120)** | 7.5 (0–90)*** |
| Pain peripheral joints (0–100) | 75 (20–99) | 12 (0–84)*** | 15 (4–31)*** | – | 28 (0–80)*** | – | 34 (1–91)* | 11.5 (1–34)*** |
| Tender joint count (0–68) | 6 (1–18) | 0 (0–5)*** | 1 (0–6)*** | 0.5 (0–5)*** | 0.5 (0–8)*** | 0 (0–4)*** | 1 (0–12)* | 0 (0–4)*** |
| Swollen joint count (0–68) | 3.5 (1–12) | 0 (0–7)*** | 0 (0–9)** | 0 (0–10)*** | 0 (0–12)*** | 0 (0–6)*** | 0 (0–9)* | 0 (0–6)*** |
| Axial assessment | (n=11) | (n=11) | (n=11) | (n=11) | (n=11) | (n=11) | ||
| Night pain (0–3) | 3 (1–3) | 1 (0–1)** | 1 (0–2)* | – | 1 (0–3)* | – | 1 (0–3)* | 0 (0–1)** |
| Morning stiffness (min) | 90 (30–240) | 5 (0–120)** | 12.5 (0–120)** | – | 15 (0–120)* | – | 60 (0–120) NS | 10 (0–200)* |
| Pain spine (0–100) | 57 (4–95) | 11 (1–60)** | 15.5 (3–62)** | – | 17 (0–81)* | – | 22 (1–88) NS | 10 (1–65)** |
| BASDAI (0–100) | 62.5 (28.8–82.4) | 11.3 (1.2–44.0)** | 15.9 (1–61.7)** | – | 26 (2.8–46.7)** | – | 42.1 (2.7–91.6)* | 11.2 (3.9–40.3)** |
| BASFI (0–100) | 77.5 (9.9–94.2) | 22.3 (1.0–63.2)** | 36.8 (1–74.4)** | – | 37.9 (4.7–73.7)** | – | 45.6 (5.8–75.3)* | 17.9 (3.9–63.9)** |
| Dougados functional index (0–40) | 21 (7–31.5) | 8.5 (0.5–21.0)** | 13.25 (1–26)** | – | 12.5 (1.5–23.5)** | – | 15 (3.5–24.0) NS | 9 (2.5–20.5)* |
| Spinal pain (0–3) | 2 (0–3) | 0 (0–2)* | 0 (0–3)* | – | 0.5 (0–3) NS | – | 0 (0–3) NS | 0 (0–3)* |
| BASMI (0–10) | 5 (3–9) | 5 (1–9)* | 4.5 (1–9)* | – | 5 (1–8)** | – | 5 (1–8)* | 4.5 (2–8)* |
| Occiput to wall (cm) | 12 (3.7–21.5) | 7.7 (2.5–22.0)** | 9 (3.5–21)* | – | 8.5 (3.8–21)* | – | 8.5 (4–20)* | 10 (2.5–20)* |
| Chest expansion (cm) | 1.8 (1.5–3.2) | 3.8 (1.7–5.5)** | 3.5 (1.7–5.5)** | – | 3.2 (1.5–5.6)** | – | 4.5 (1.8–5.5)** | 4.5 (2.0–6.0)** |
| Fingers to floor (cm) | 24 (5.5–38.0) | 15 (0–20.3)** | 10.5 (0–33.8)** | – | 15.6 (7.2–36.5)** | – | 17.5 (0–31)* | 17.4 (0–31)* |
| Dougados articular index (0–30) | 6 (1–15) | 0 (0–4)** | 0.5 (0–4)** | – | 2 (0–11)* | – | 1.5 (0–8)** | 0 (0–4)** |