Table 7

Results of the transmission disequilibrium test performed for HLA-DR alleles carried on HLA-B27 negative haplotypes*

Patients (n=156)Unaffected HLA-B27+ siblings (n=70)
HLA-DR allele†TransmittedNot transmittedp/pcorr‡TransmittedNot transmittedp‡Unmatched χ2p/pcorr§
*NA, statistical analysis not applicable because of small sample size. pcorr=p value corrected for the number of comparisons; †number of alleles DR9, DR10, and DR12 available for transmission disequilibrium test were too small to give valid results; ‡p values were obtained using binomial probability; §p values were obtained using χ2 test to compare the balance of transmission between patients and HLA-B27+ siblings.
DR113100.538810.160.69
DR216260.1312110.841.20.27
DR314180.48840.251.830.18
DR42060.006/0.05280.069.850.002/0.012
DR720201980.810.040.84
DR810110.8334NANANA
DR1120160.51790.620.620.43
DR1313180.37850.412.20.14
DR14870.813NANANA