Results of the transmission disequilibrium test performed for HLA-DR alleles carried on HLA-B27 negative haplotypes*
| Patients (n=156) | Unaffected HLA-B27+ siblings (n=70) | |||||||
|---|---|---|---|---|---|---|---|---|
| HLA-DR allele† | Transmitted | Not transmitted | p/pcorr‡ | Transmitted | Not transmitted | p‡ | Unmatched χ2 | p/pcorr§ |
| *NA, statistical analysis not applicable because of small sample size. pcorr=p value corrected for the number of comparisons; †number of alleles DR9, DR10, and DR12 available for transmission disequilibrium test were too small to give valid results; ‡p values were obtained using binomial probability; §p values were obtained using χ2 test to compare the balance of transmission between patients and HLA-B27+ siblings. | ||||||||
| DR1 | 13 | 10 | 0.53 | 8 | 8 | 1 | 0.16 | 0.69 |
| DR2 | 16 | 26 | 0.13 | 12 | 11 | 0.84 | 1.2 | 0.27 |
| DR3 | 14 | 18 | 0.48 | 8 | 4 | 0.25 | 1.83 | 0.18 |
| DR4 | 20 | 6 | 0.006/0.05 | 2 | 8 | 0.06 | 9.85 | 0.002/0.012 |
| DR7 | 20 | 20 | 1 | 9 | 8 | 0.81 | 0.04 | 0.84 |
| DR8 | 10 | 11 | 0.83 | 3 | 4 | NA | NA | NA |
| DR11 | 20 | 16 | 0.51 | 7 | 9 | 0.62 | 0.62 | 0.43 |
| DR13 | 13 | 18 | 0.37 | 8 | 5 | 0.41 | 2.2 | 0.14 |
| DR14 | 8 | 7 | 0.8 | 1 | 3 | NA | NA | NA |