Radiographic progression of joint damage in the intention to treat population (n=272, mean (SD) and median (IQR))
| Cyclosporin (n = 121)* | Gold (n = 121)* | ||||
|---|---|---|---|---|---|
| Mean (SD) | Median (IQR) | Mean (SD) | Median (IQR) | p Value† | |
| IQR, interquartile range | |||||
| *Thirty patients failed to provide complete x ray findings between baseline and month 36; †p value from two way analysis of covariance for baseline comparisons and from two way analysis of covariance for change from baseline comparisons. | |||||
| Larsen-Dale score | |||||
| Baseline | 14.8 (18.8) | 8 (0-24) | 14.0 (18.9) | 6 (0-22) | 0.81 |
| Increase from baseline by month 18 | 10.0 (13.1) | 6 (0-17) | 10.3 (13.1) | 6 (0-14) | 0.42 |
| Increase from baseline by month 36 | 15.5 (17.3) | 12 (0-25) | 13.9 (17.2) | 10 (1-20) | 0.52 |
| Number of eroded joints | |||||
| Baseline | 4.0 (5.1) | 2 (0-7) | 4.0 (5.2) | 2 (0-7) | 0.60 |
| Increase from baseline by month 18 | 2.6 (3.3) | 2 (0-4) | 2.8 (4.2) | 1 (0-4) | 0.68 |
| Increase from baseline by month 36 | 3.7 (4.3) | 3 (0-6) | 3.8 (5.4) | 2 (0-5) | 0.61 |
| Number of erosions | |||||
| Baseline | 7.5 (13.2) | 2 (0-10) | 7.5 (13.6) | 2 (0-9) | 0.67 |
| Increase from baseline by month 18 | 5.8 (9.4) | 3 (0-8) | 5.3 (8.5) | 2 (0-6) | 0.25 |
| Increase from baseline by month 36 | 10.0 (13.3) | 6 (1-15) | 8.4 (11.7) | 4 (1-12) | 0.30 |