Risk factors indicative of radiographic damage in early RA
| Author (reference) | Study design | Risk factors at baseline | Evidence category |
|---|---|---|---|
| Table adapted from Kim JM and Weisman MH.18 | |||
| Brennan et al50 | Prospective study of 157 patients with RA for 1 year | RF ≥1/80, involvement of ≥2 large joints and >3 months' disease duration | III |
| Combe et al51 | Prospective study of 191 patients with RA for 3 years | RF positive, ESR, DRB1*04 gene, and erosion score | III |
| Feigenbaum et al52 | Prospective study of 50 patients for ≥3 years | Involvement of ≥2 swollen joints, white female, Raynaud's symptoms, presence of malaise or weakness | III |
| Gough et al53 | Prospective study of 120 patients with RA for 1 year | RF positive and HLA-Dw4 or HLA-Dw14 positive | III |
| Möttönen et al54 | Prospective study of 142 patients with RA for 6 years | High disease activity at baseline, RF positive especially at 1 year | III |
| van der Heide et al55 | Prospective study of 128 patients with RA for 1 year | RF positive, with radiographic damage evident at 1 year | III |
| van der Heijde et al56 | Prospective study of 147 patients with RA for ≥2 years | High disease activity at presentation or CRP levels, ESR or DAS, DR4+ or DR2−, RF positive | III |
| van der Horst-Bruinsma et al35 | Prospective study of 139 patients with RA for 1 year | RF positive and arthritis of hands and feet | III |
| van Leeuwen et al57 | Prospective study of 149 patients with RA for 3 years | Raised CRP and ESR and swollen joints | III |
| van Zeben et al58 | Prospective study of 132 patients with RA for 6 years | RF positive, number of swollen joints, and erosion score | III |