Table 1

An overview of three sets of classification criteria for patients Sjögren's syndrome

Name and year first introduced	American-European consensus group 2002*⁵	Japanese expert group 1999†⁶	Copenhagen criteria 1974–75‡⁴
KCS, keratoconjunctivitis sicca; FS, focus score in lower lip biopsy.
*For the diagnosis of primary SS, positive anti-SSA/SSB autoantibodies and/or abnormal FS is mandatory plus at least four of six items; †For the diagnosis of primary SS, two of four different items should be positive; ‡For the diagnosis of primary SS, two abnormal functional tests from the eyes and mouth are required.
Require subjective ocular symptoms	Yes	No	No
Require objective oral symptoms	Yes	No	No
Minimum number of abnormal oral objective tests required for the diagnosis of KCS	1	2	2
How many abnormal objective tests required for the diagnosis of stomatitis sicca?	1	2	2
Requirement for abnormal FS?	≥1 focus per 4 mm²	≥1 focus per 4 mm²	>1 focus per 4 mm²
Positive anti-SSA/SSB autoantibodies and or abnormal FS?	Absolute requirement	Not mandatory	Not mandatory
Will usually miss past and/or present cigarette smokers?	Yes	No	No