Risk factors at disease onset for a higher mortality in patients with SLE
| All | Not alive | |||||
|---|---|---|---|---|---|---|
| No | % | % | t | p | RR (95% CI) | |
| Multivariable Cox regression; age and sex adjusted. *Results for Ro, nRNP antibodies are calculated with χ2 tests, as a Cox regresion is not possible with zero values; NC, not calculated. | ||||||
| t=years after diagnosis, when 25% of the patients have died. | ||||||
| Heart disease includes carditis, coronary heart disease, myocardial infarction and congestive heart failure. CNS disease includes psychosis, seizure, stroke, haemorrhage, CNS vasculitis. Reduced creatintine clearance: <70 ml/min. | ||||||
| All patients with SLE | 338 | 100 | 10 | 17.8 | – | – |
| Risk factors: | ||||||
| Heart disease | 25 | 7 | 28 | 10.4 | 0.05 | 1.5 (1.0 to 2.4) |
| CNS disease | 33 | 10 | 18 | 10.4 | 0.06 | 1.6 (0.98 to 2.5) |
| Nephritis (ACR) | 77 | 23 | 20 | 10.4 | <0.05 | 1.6 (1.1 to 2.4) |
| Reduced creatinine clearance | 39 | 12 | 33 | 9.7 | <0.01 | 1.8 (1.2 to 2.7) |
| Protective factors: | ||||||
| Ro antibodies* | 38 | 11 | 0 | NC.* | <0.05* | 0.1* |
| nRNP antibodies* | 32 | 9 | 0 | NC* | <0.05* | 0.1* |