Levels of acute phase response during the attack and attack-free periods in patients with FMF in comparison with those in the control groups (mean (SD))
| APR and urine analysis | FMF, during attack (n=49) | FMF, attack-free (n=49) | Positive controls (n=39) | Healthy controls (n=19) |
|---|---|---|---|---|
| ap<0.0001; bp<0.001; cp<0.0001; dp<0.002; ep<0.01; fp<0.05 attack v attack-free periods by Wilcoxon test. gp<0.0005; hp<0.03; ip<0.002; jp<0.02; kp<0.001 positive control group v attack by Mann-Whitney U test. After the value (SD) the next parentheses+ give the number, of patients with levels above normal/to the number of patients tested; ++ the final parentheses give the percentage of patients above normal. For albumin, it is the number of patients below normal levels. *The number of patients undergoing protein electrophoresis was 24. Parentheses refer to percentage of patients with levels above normal. ¶Normal values for ferritin: 10–292 ng/ml for women; 22–322 ng/ml for men). | ||||
| ESR (>20 mm/1st h) | 52 (27)a (43/49)+ (88)++ | 20 (12) (22/42) (52) | 75 (32)g (39/39) (100) | 5 (0. 03) (0/19) |
| CRP (>6 mg/l) | 139 (110)a (49/49) (100) | 22.1 (38) (15/44) (34) | 118 (100) (36/39) (92) | 5 (0.3) (1/19) (5) |
| Fibrinogen (>4 g/l) | 4.13 (1.11)b (15/24) (63) | 2.82 (0.83) (1/24) (4) | 3.72 (1.37) (8/26) (31) | 2.50 (0.79) (0/10) |
| Haptoglobin (>2.70 g/l) | 2.67 (0.81)c (10/24) (42) | 1.74 (0.85) (3/24) (13) | 2.92 (1.01) (17/26) (65) | 1.43 (0.68) (0/10) |
| WBC (>10×109/l) | 10.6 (3.9)c (12/24) (50) | 7.5 (2.3) (3/24) (13) | 10.3 (5.4) (12/26) (46) | 7.3 (1.3) (0/10) |
| Platelets (>400×109/l) | 255.8 (62.1) (0/45) | 246.5 (64.9) (0/42) | 395.7 (163.2)i (17/39) (44) | 248.0 (59.1) (0/19) |
| Ferritin (ng/ml)¶ | 127 (113)d (1/25) (4) | 72 (52) (0/25) | 1159 (1775)h (8/13) (62) | 80 (59) (0/9) |
| FVIIIRAg (>200%) | 147 (130)e (3/17) (18) | 61 (43) (0/17) | 197 (212) (7/21) (33) | 78 (43) (0/7) |
| Protein electrophoresis* | ||||
| α1 Globulin (g/l) | 1.8 (0.7)f | 1.3 (0.6) | 1.7 (0.7) (1/26) (4) | 1.3 (0.4) |
| α2 Globulin (g/l) | 9.6 (2)b (4/24) (17) | 7.4 (1) (0/24) | 8.1 (2.1)j (2/26) (8) | 6 (0.9) |
| β Globulin (g/l) | 3.7 (3) (3/24) (13) | 8.6 (1) (1/24) (4) | 8.1 (2.5) (2/26) (8) | 8.3 (1.3) |
| γ Globulin (g/l) | 12.1 (3) (2/24) (8) | 12.2 (3) (2/24) (8) | 14.1 (6.2) (6/26) (23) | 9.8 (2.5) |
| Albumin (<35 g/l) | 45 (6) (1/23) (4) | 46 (6) (2/22) (9) | 34 (9)k (10/26) (38) | 52 (4) (0/10) |
| Proteinuria ≥ trace | 10/24 (42) | 1/24 (4) | 9/26 (35) | 1/10 (10) |
| Haematuria ≥5RBC | 3/24 (13) | 0/24 | 5/26 (19) | 0/10 |