Table 2

Purine enzyme activities at baseline and changes from baseline after six and 48 weeks*. Values are shown as the mean (95% confidence interval).

Baseline (n=103)Week 6 − baseline (n=103)Week 48 − baseline (n=76)
*Enzyme activities are expressed in nmol/106 mononuclear cells/h of incubation. Reference values (from our laboratory obtained in patients with rheumatoid arthritis and healthy controls in former studies and partly published by Stolk et al24): 5`NT = 13.7 (SD 3.6) for men, 20.4 (SD 4.7) for women; ADA = 134 (SD 46); PNP = 212 (SD 54); HGPRT = 12.3 (SD 4.2).
5`NT16.9 (15.0 to 18.8)2.1 (−0.6 to 4.8)0.4 (−1.2 to 2.1)
ADA80.3 (74.9 to 85.7)−1.5 (−10.2 to 7.3)−21.6 (−28.6 to −14.7)
PNP206.8 (182.6 to 230.9)−6.5 (−40.7 to 27.7)−78.9 (−109.0 to −48.7)
HGPRT8.7 (8.0 to 9.4)−0.1 (−1.1 to 0.8)−2.0 (−3.1 to −0.9)