HSP70-2 and HSP70-hom genotype and allele frequencies (%) in B27 negative Mexican patients with SpA and healthy controls
| HSP70-2 | SpA (n=54) No (%) | AS (n=10) No (%) | uSpA (n=35) No (%) | ReA (n=9) No (%) | Controls (n=154) No (%) |
|---|---|---|---|---|---|
| Genotype | |||||
| A/A | 15 (28) | 3 (30) | 9 (26) | 3 (33) | 34 (22) |
| A/B | 28 (52)* | 5 (50) | 20 (57) | 3 (33)* | 113 (73) |
| B/B | 11 (20)* | 2 (20)* | 6 (17)* | 3 (33)* | 7 (5) |
| OR=5.3 | OR=5.2 | OR=4.3 | OR=10.5 | ||
| AF=16.5% | AF=16.1% | AF=13.1% | AF=30.1% | ||
| Alleles | |||||
| A | 58 (54) | 11 (55) | 38 (54) | 9 (50) | 181 (59) |
| B | 50 (46) | 9 (45) | 32 (46) | 9 (50) | 127 (41) |
| HSP70-hom | SpA(n=47) | AS(n=8) | uSpA(n=32) | ReA(n=7) | Controls(n=154) |
|---|---|---|---|---|---|
| *pC<0.05. | |||||
| OR, odds ratio; AF, aetiological fraction. | |||||
| Genotype | |||||
| A/A | 41 (87)* | 7 (88) | 28 (88)* | 6 (86) | 95 (62) |
| OR=4.2 | OR=4.3 | ||||
| AF=66.6% | AF=67.3% | ||||
| A/B | 5 (11)* | 1 (13) | 4 (13)* | 0 (0) | 54 (35) |
| B/B | 1 (2) | 0 (0) | 0 (0) | 1 (14) | 5 (3) |
| Alleles | |||||
| A | 87 (93)* | 15 (94) | 60 (94)* | 12 (86) | 244 (79) |
| OR=3.2 | OR=3.8 | ||||
| AF=64.1% | AF=69.8% | ||||
| B | 7 (7)* | 1 (6) | 4 (6)* | 2 (14) | 64 (21) |