Table 3

Cytokine profile of peripheral blood CD3+ T cells and CD3+/CD56+ NK T cells in healthy controls (HC), patients with spondyloarthropathy (SpA) at baseline, and patients with rheumatoid arthritis (RA)

CD3+ CD3+/CD56+ p Value
HC (n=15)
 IFNγ33.0  (13.1–53.9)19.1  (8.2–48.4)0.019
 IL225.7 (13.4–39.6)19.2 (1.0–36.0)0.049
 IL41.8 (0.4–3.6)13.2 (1.3–35.8)0.000
 IL101.1 (0.2–5.6)33.5 (11.3–55.9)0.000
SpA (n=20)
 IFNγ20.9 (9.5–65.1)16.2 (3.9–70.8)NS
 IL217.5 (7.5–35.4)12.5 (2.2–51.8)0.011
 IL41.5 (0.3–8.7)11.1 (0.2–68.0)0.000
 IL103.8 (0.9–15.4)42.8 (6.5–82.4)0.000
RA (n=19)
 IFNγ19.9 (8.4–53.4)11.8 (4.5–48.1)0.019
 IL231.2 (13.1–56.7)11.4 (2.5–33.1)0.000
 IL41.0 (0.3–2.7)3.0 (0.2–14.4)0.005
 IL105.4 (1.8–37.5)38.1 (10.3–68.0)0.000
  • NS = not significant.

  • Percentage of positive cells for interferon (IFN)γ, interleukin (IL)2, IL4, and IL10 was assessed by flow cytometry. Results are expressed as median (range) % of CD3+ cells and CD3+/CD56+ cells expressing IFNγ, IL2, IL4, and IL10