Table 2

Doses of drugs used in B lymphocyte depletion

CohortPatientmAb treat. (mg/m2BSA )Cyclophosphamide (mg)Prednisolone (mg)ESR at baseline (mm/1st h)ESR at 6 months (mm/1st h)CRP at baseline (mg/l)CRP at 6 months (mg/l)ACR grade of improvement at 6 months*Time to B cell repopulation (months)Time to relapse (months)
*All responses calculated relative to baseline status; † reduced for subjects <50 kg; ‡ see text.
BSA, body surface area; NA, not applicable; ESR, erythrocyte sedimentation rate; CRP, C reactive protein.
I1140015008506510 71.4 370 20.8 33.5
21400150013003810 72 2.870 6.9 6.9
31400150012503623 9.8 3.470 8.8 25.6
41400150014259258 96.8 26.750 7.4 7.8
5900150011002411 14.7 3.150 11.1 21.2
II2a30082220 0 0NA
67005149 75.5 53 0 4.6NA
77006409049 96.9 32.720 8.3 7.2
860060526 39.7 0 3.5NA
III2b60022504002911 66.8 370 6.7 6.7
4a60015006009024 93.4 10.370 9.9 9.5
6a60015005004933 53.2 2420>18.2 5.8
7a7001000†3007211 52.1 1520 7.8 11.3
960015004206817 38.5 14.270 6.7 7.4
107001000†4008124 31 2.570 8.5 9
10a7001000†4004025 11.4 2.770 6.2 >9
1160015005006633 8.6 2.770 10.4>20.3
1260015006004615 4.4 550 6.5 11.5
12a60015006002212 15.9 5.750 6.7 >6.7
IV1312001500-115 8.1 170 54>15.5
1412001000†-5111 40.8 4.650 10.2 12.2
1512001500-4014 37.9 31.920‡ 17.1NA
1612001000†-6135103 59.120 9.5 17.3
1712001500-3631 12 9.150 6 13.2
18120015002405820 52.5 46.570 5.8 7.4
V1950015002105965 26.9111.7 0 8.5NA
2050015003007273 87.6 80 0 6.9NA
21500150034042110 15.6109.6 0 9.2NA
2250015001504233 8.8 5.9 0 5.1NA