|
Synthesis
|
Breakdown
|
Bone |
Type I collagen | • Procollagen propeptides | • Crosslinks |
- PINP, PICP | - DPYD, PYD |
• Telopeptides |
- NTX, CTX, ICTP |
Non-collagenous proteins | • Bone-specific ALP | • TRAP |
• Osteocalcin | • BSP |
Cartilage
|
Aggrecan | • Chondroitin sulphate | • Core protein fragments |
- 846, 3B3, 7D4 | • Keratan sulphate |
- 5D4 |
- AN9P1 |
Type II collagen | • Procollagen propeptides | • Crosslinks |
- PIICP, PIIANP | - PYD |
• Collagenase epitopes |
- COL2-3/4m |
- COL2-1/4N1 |
• Collagen II telopeptides |
- CTX-II |
Other proteins | • YKL-40 | • COMP |
| |
Synovium
|
Types I and III collagens | • Procollagen propeptides | • PYD |
- PICP, PIIINP | - Glc-Gal-PYD |
• CTX |
Non-collagen protein | • Hyaluronan | |
• YKL-40 |
• COMP |
• MMP-1, -2, -3, -9 |
• TIMP-1, -2 |