Table 1

Cardiological complications in long term treatment with chloroquine and hydroxychloroquine in systemic autoimmune diseases. All the patients were female

Authors Age Disease Cardiac complications Other complications Total dose
Verny3 56SLECHBNeuromyopathy1168 g CQ
Verny3 55MCTDRight and left posterior blockadeRetinopathy600 g CQ
Ratcliff4 59SLECHFNA292 g HCQ
Ratcliff4 58DLCHF, CHB, RMCNA730 g HCQ, 1095 g CQ
Cubero5 59DLCHB, RMCMyopathy, dead2281 g CQ
Reuss-Borst6 73RACHBNeuromyopathy912 g CQ
Reuss-Borst6 40SLECHBRetinopathyNA
Baguet7 58SLERight blockade, first degree block, HMCNeuromyopathy4380 g HCQ, 657 g CQ
Veinot8 60RA, SS, RaynaudCHB, CHFNeuromyopathy, dead912 g CQ
McAllister9 33SLEHMCMyopathy1003 g CQ
McAllister9 70SLEHMCDead912 g CQ
Guedira10 43RACHBHyperpigmentation724 g CQ
  • SLE = systemic lupus erythematosus; MCTD = mixed connective tissue disease; DL = discoid lupus; RA = rheumathoid arthritis; SS = Sj√∂gren's syndrome; CHB = complete heart block; CHF = congestive heart failure; RMC = restrictive myocardiopathy; HMC = hypertrophic myocardiopathy; CQ = chloroquine; HCQ = hydroxychloroquine; NA = not available.