Table 1

Cardiological complications in long term treatment with chloroquine and hydroxychloroquine in systemic autoimmune diseases. All the patients were female

Authors	Age	Disease	Cardiac complications	Other complications	Total dose
Verny³	56	SLE	CHB	Neuromyopathy	1168 g CQ
Verny³	55	MCTD	Right and left posterior blockade	Retinopathy	600 g CQ
Ratcliff⁴	59	SLE	CHF	NA	292 g HCQ
Ratcliff⁴	58	DL	CHF, CHB, RMC	NA	730 g HCQ, 1095 g CQ
Cubero⁵	59	DL	CHB, RMC	Myopathy, dead	2281 g CQ
Reuss-Borst⁶	73	RA	CHB	Neuromyopathy	912 g CQ
Reuss-Borst⁶	40	SLE	CHB	Retinopathy	NA
Baguet⁷	58	SLE	Right blockade, first degree block, HMC	Neuromyopathy	4380 g HCQ, 657 g CQ
Veinot⁸	60	RA, SS, Raynaud	CHB, CHF	Neuromyopathy, dead	912 g CQ
McAllister⁹	33	SLE	HMC	Myopathy	1003 g CQ
McAllister⁹	70	SLE	HMC	Dead	912 g CQ
Guedira10	43	RA	CHB	Hyperpigmentation	724 g CQ

SLE = systemic lupus erythematosus; MCTD = mixed connective tissue disease; DL = discoid lupus; RA = rheumathoid arthritis; SS = Sjögren's syndrome; CHB = complete heart block; CHF = congestive heart failure; RMC = restrictive myocardiopathy; HMC = hypertrophic myocardiopathy; CQ = chloroquine; HCQ = hydroxychloroquine; NA = not available.