Table 3

Percentage of cytokine-producing CD3+, CD3+CD8+ and CD3+CD8− T cells in ileum epithelium and lamina propria from healthy controls (C) and patients with spondyloarthropathy (SpA) after stimulation withPMA/ionomycin

CD3+CD3+CD8+CD3+CD8−
CSpACSpACSpA
IELsn=9n=16n=9n=16n=9n=16
IFNγ33 (20–67)33 (10–63)52 (31–74)43 (10–72)15 (4–53)21 (9–44)
IL250 (6.3–79)54 (15–80)64 (7–84)63 (14–87)42 (4–69)43 (15–66)
IL41.1 (0.2–2)0.7 (0.2–1.9)0.7 (0.4–1.3)0.6 (0.1–1.9)1.2 (0.5–1.9)0.7 (0–2)
IL103.9 (2.9–9.7)4.9 (1.3–14)3.8 (2.9–9.3)4.7 (1.1–12)3.1 (2.6–9.7)6.1 (1.6–15)
LPLsn=10n=16n=9n=15n=9n=15
IFNγ65 (13–82)51 (17–72)77 (35–89)65 (23–85)58 (5.4–74)39 (12–66)
IL283 (26–89)62 (19–83)88 (30–88)62 (18–92)81 (8.8–89)64 (21–85)
IL41.6 (0.6–3.8)1.3 (0.2–5.4)1.1 (0.4–3.8)1.3 (0.2–11.9)2 (0.4–3.8)0.8 (0–3.3)
IL102.5 (1.1–4.1)3.3 (1.1–13)2.1 (0.6–4.8)3 (0.9–14.3)2.4 (1.1–4.5)3.4 (1.3–19)3-150
  • Results are expressed as the median (range).

  • 3-150 p<0.05 compared with controls.

  • IFN = interferon; IL = interleukin; IEL = intraepithelial lymphocyte; LPL = lamina propria lymphocyte; PMA = phorbol 12-myristate 13-acetate.