Table 2

Percentage of cytokine-producing CD3+, CD3+CD8+, and CD3+CD8− T cells in colon epithelium and lamina propria from healthy controls (C) and patients with spondyloarthropathy (SpA) after stimulation with PMA/ionomycin

CD3+CD3+CD8+CD3+CD8−
CSpACSpACSpA
IELsn=10n=19n=8n=17n=8n=17
IFNγ29 (15–65)26 (9–45)42 (18–77)40 (14–67)19 (9–38)20 (7–30)
IL243 (16–66)43 (17–67)37 (12–85)44 (11–73)47 (20–58)41 (20–61)
IL41.1 (0.2–3.6)0.9 (0.2–2.7)0.9 (0.1–2.7)0.9 (0.4–2.6)1.1 (0–4.4)1 (0.1–2.8)
IL102.9 (0.1–4.8)3 (1.4–5.7)2.2 (0.1–4.2)2.1 (1.1–6.1)4.2 (0.1–5.9)3.5 (1.4–7.5)
LPLsn=10n=18n=9n=18n=9n=18
IFNγ64 (42–72)54 (19–73)2-150 78 (53–88)67 (30–84)57 (37–67)47 (15–70)2-150
IL271 (49–85)67 (21–74)60 (38–87)60 (15–81)74 (47–84)67 (21–78)2-150
IL41.8 (0.9–4.2)1.7 (0.4–5.3)3.4 (0.7–6.5)2.9 (0.6–16)1.4 (0.5–3.2)1.3 (0–5.3)
IL103 (1.4–7.3)3.7 (1.9–6.8)3 (1.1–7.9)4.2 (1.8–10.2)2.6 (1.5–6.9)3.3 (0.5–7)
  • Results are expressed as the median (range).

  • 2-150 p<0.05 compared with controls.

  • IFN = interferon; IL = interleukin; IEL = intraepithelial lymphocyte; LPL = lamina propria lymphocyte; PMA = phorbol 12-myristate 13-acetate.