Table 1

Examples of MMP involvement in tissue remodelling in normal and pathological conditions. Adapted with permission from ref 12.

Normal Pathological
DevelopmentRheumatoid arthritis
Wound healingOsteoarthritis
Joint remodellingMetastases
Tissue homoeostasisPeriodontal disease
OvulationAngiogenesis
Trophoblast implantationEmphysema
Postpartum uterus involutionMultiple sclerosis
Left ventricular remodelling
Aortic aneurysm