Osteoarthrosis severity and prevalence after inactivation (“knockout”) of one allele of the Col2a1 gene
| Group | Grade 0 (%) | Grade 1 (%) | Grade 2 (%) | Grades 3 and 4 (%) |
| Heterozygous Col2a1 knockouts (n=15) | 26.7 | 66.7 | 6.6 | 0.0 |
| –––––––1-150p=0.002–––––––– | ||||
| Control mice (n=19) | 78.9 | 21.1 | 0.0 | 0.0 |
↵1-150 Comparison of healthy (grade 0) and diseased (pooled grades from 1 to 4) OA scores between knockout and control mice by χ2 statistics.
Grades: 0 = intact articular cartilage; 1 = superficial lesions not affecting the intermediate zone; 2 = lesions extending to the intermediate zone; 3 and 4 = lesions reaching the deep cartilage and subchondral bone, respectively.