Deaths after the start of the procedure. The details relevant to the deaths of all patients registered with EBMT for haemopoietic stem cell transplantation in systemic sclerosis. The deaths are categorised by the relation to the procedure. In patients who died after the mobilisation regimen, but before conditioning, the survival time is listed as 0 days. Otherwise, the transplant date is taken as day 0
Sex | Age | Graft | Priming | Conditioning | Purge | Disease pattern | Organ involvement | Survival (days) | Cause of death | |||||||||
Procedure related deaths | ||||||||||||||||||
M | 33.6 | NT3-150 | Cy 3-150+ G-CSF3-150 | None | None | Diffuse | L3-150, O3-150 | 0 | Sudden cardiac death, coronary atherosclerosis at necropsy | |||||||||
F | 50.1 | NT | Cy +G-CSF | None | None | Limited | L, PAH3-150 | 0 | Neutropenic fever, pneumonia, cardiac failure | |||||||||
F | 38.0 | NT | Cy +G-CSF | None | None | Diffuse | L, O | 0 | Thrombocytopenia, pulmonary haemorrhage, myocarditis? | |||||||||
F | 18.9 | ASCT3-150 | G-CSF | Cy +ATG3-150 | None | Diffuse | L | 11 | Diffuse alveolar haemorrhage | |||||||||
F | 41.0 | ASCT | G-CSF | Cy +ATG + TBI3-150 | CD34 | Diffuse | L, O | 28 | Interstitial pneumonitis | |||||||||
M | 47.2 | ASCT | Cy +G-CSF | Cy | NA3-150 | Diffuse | L, GI3-150, R3-150 | 40 | Central nervous system bleed | |||||||||
F | 57.3 | ASCT | G-CSF | Cy +ATG + TBI | CD34 | Diffuse | L, GI | 79 | Interstitial pneumonitis | |||||||||
Disease related deaths | ||||||||||||||||||
M | 45.1 | NT | Cy +G-CSF | None | None | Diffuse | L, O, PAH | 0 | Disease progression | |||||||||
F | 54.1 | ASCT | Cy +G-CSF | BCNU3-150, thiotepa, fludarabine | CD34 | Diffuse | L, O, PAH | 217 | Pulmonary hypertension | |||||||||
F | 38.1 | ASCT | Cy +G-CSF | Cy | CD34 + CAMPATH | Diffuse | L, O | 242 | Disease progression | |||||||||
F | 42.0 | ASCT | Cy +G-CSF | Cy | CD34 + CAMPATH | Diffuse | A3-150 | 527 | Superior vena cava obstruction | |||||||||
Disease progression |
↵3-150 NT = not transplanted; ASCT = autologous stem cell transplant; Cy = cyclophosphamide; G-CSF = granulocyte colony stimulating factor; ATG = anti-thymocyte globulin; TBI = total body irradiation; BCNU = 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine); NA = data not available. Organ involvement: L = lung; O = oesophageal; PAH = pulmonary hypertension; GI = gastrointestinal; R = renal; A = arthropathy.