Expression levels of Tie-1 and Tie-2 in the rheumatoid synovium of each patient
| Patient No | Tie-1 | Tie-2 | |||||
|---|---|---|---|---|---|---|---|
| Lining | Sublining | Vessels | Lining | Sublining | Vessels | ||
| 1 | +/− | +/− | +/− | +/− | +/− | + | |
| 2 | +/− | +/− | +/− | + | + | ++ | |
| 3 | + | ++ | +/− | +/− | +/− | + | |
| 4 | ++ | ++ + | ++ + | ++ | ++ | +++ | |
| 5 | +/− | +/− | +/− | + | + | ++ | |
| 6 | + | +/− | + | +++ | + | +++ | |
| 7 | +/− | +/− | +/− | ++ | ++ | ++ | |
| 8 | +/− | +/− | +++ | ++ | +++ | +++ | |
| 9 | +/− | +/− | + | + | +/− | ++ | |
| 10 | + | +/− | +/− | ++ | + | ++ | |
+++, ++, +, and +/− represent staining frequencies of >50%, 20–50%, 5–20%, and <5%, respectively, as described in “Materials and methods”. Serial sections were stained in two separate procedures, and showed the same results.