Table 3

Infiltration by CD3+ T cells, CD4+ cells, CD 8+ cells, CD68+ macrophages, and expression of the adhesion molecules ICAM-1 and VCAM-1 and the activation antigen HLA-DR in muscle biopsy specimens of patients with RA and clinical signs of vasculitis without histological proof (RA+) and of patients with RA with vasculitis (RV) proved by the presence of fibrinoid necrosis of vessel walls or another histological gold standard for the diagnosis of vasculitis, according to the absence (PVI−) or presence (PVI+) of a perivascular infiltrate of more than three cell layers on routine histology. Values are the mean semiquantitative scores (standard error of the means)

CD3 CD4 CD8 CD68 ICAM-1 VCAM-1 HLA-DR
RA+ PVI− (n=7)1.310.821.50.92.1
RV PVI− (n=3)11.31.3331.32.3
All PVI− (n=10)1.2 (0.1)1.1 (0.1)1 (0.2)2.3 (0.3)1.9 (0.3)1 (0.2)2.2 (0.2)
RA+ PVI+ (n=4)2.52.22.32.72.72.23.5
RV PVI+ (n=11)2.32.31.92.62.72.12.9
All PVI+ (n=15)2.33-150 (0.2)2.33-150 (0.2)23-150 (0.3)2.6 (0.2)2.7 (0.3)2.13-150 (0.2)3.13-150 (0.2)
  • 3-150 p<0.05 (Student's t test comparing PVI− and PVI+).