Arguments for a dominant role of IL1 in destructive arthritis
| Higher arthritogenic potency of IL1 compared with TNF |
| TNF induced arthritis can be fully blocked with IL1R antibodies |
| TNF independent IL1 production occurs in many arthritis models |
| Greater net efficacy of anti-IL1 as compared with anti-TNF treatment in many models |
| Erosive arthritis can still be induced in TNF deficient mice |
| No erosive experimental arthritis in IL1b deficient mice |
| Spontaneous destructive arthritis occurs in IL1Ra deficient mice |