Table 1

Clinical details of 30 patients each fulfilling diagnostic criteria for “definite” or “probable” primary Sjögren's syndrome (SS)⁸

		Age diag.		Year diag.		Duration symptoms		Schirmer's		RB stain		Lip biopsy		Ro		La		Xero− stomia		Dyspnoea			Cigs./day			Tlco(SR)		Kco(SR)		CXR
		Age diag.		Year diag.		Duration symptoms		R	L	RB stain		Lip biopsy		Ro		La		Xero− stomia		(0)	(4)		(10)	(0)		(4)	(10)	(0)	(4)	(10)	(0)	(4)	(10)	(0)	(4)	(10)
1	50	1988	5	2	0	+	+	−	−	+	−	−	−		15	−	−		−1.05	−1.95	−0.74	0	−0.2	−0.38	N	N	N
2^1-150	48	1987	10	3	5	+	+	+	−	+	+	+	+		−	−	−		−2.3	−2.5	−1.2	−1.1	−1.45	−1.59	PT	FA	FA
3	57	1988	4	5	7	+	−	−	−	+	−	−	−		−	−	−		−0.3	−0.1	0.49	0.4	−0.2	0.38	N	N	N
4^1-150	40	1986	2	25	20	−	+	+	+	+	+	+	+		−	−	−		−2.1	−2.7	−0.7	−1	−1.1	−1.31	FA	FA	FA
5^1-151	43	1987	2	6	7	ND	−	−	−	+	−	−			−	−			−0.4	−1.5		−0.55	−0.6		N	N
6	38	1987	3	3	4	ND	−	−	−	+	−	−	−		−	−	−		−0.5	−0.7	0.68	0.55	0.35	1.55	N	N	N
7	55	1987	3	2	0	ND	−	−	−	+	−	+	+		20	20	20		0.9	0.95	1.23	−0.1	−0.45	0.59	N	N	N
8^1-150	63	1987	1	8	4	+	+	−	−	+	+	+			−	−			−3.15	−4.1		−2.05	−1.55		FA	FA
9^1-150	75	1987	15	4	5	+	+	+	−	+	+	+			−	−			−2.05	−3.1		−0.9	−0.9		N	N
10	46	1987	1	0	0	+	+	−	−	+	−	+	+		−	−	−		0.5	0.1	0.94	0.4	0	1.45	N	N	N
11	65	1986	10	0	0	+	+	+	−	+	−	−	−		−	−	−		0.2	0.4	0.61	−0.1	−0.2	0.14	N	N	N
12	76	1987	4	1	2	ND	−	−	−	+	+	+			−	−			0.3	−1		−0.5	−0.65		N	N
13	61	1987	10	0	0	+	−	+	−	+	−	−	+		−	−	−		1.2	0.8	0.56	0.2	−0.4	1.17	N	N	N
14	69	1987	4	12	15	+	+	−	−	+	+	+	+		−	−	−		1.2	0.95	1.52	0.65	0.4	1.41	N	N	CM
15	39	1987	4	0	0	+	+	−	−	+	+	+	+		−	−	−		0.15	0	0.18	−0.05	−0.1	0.62	N	N	N
16^1-150	54	1986	10	2	4	+	+	+	−	+	+	+	+		−	−	−		−1.8	−1.95	−1.7	−1	−1.1	−2.41	N	FA	FA
17	61	1988	1	7	5	−	−	−	−	+	−	−	−		−	−	−		1.6	1.05	1.24	0	−0.1	0.31	N	N	N
18	54	1988	6	0	0	+	+	−	−	+	−	+	+		−	−	−		−1.2	−1.5	0.09	−0.05	−0.3	0.41	N	N	N
19	54	1987	1	0	0	+	+	+	−	+	−	+	+		15	10	10		−0.7	−1	−0.15	−0.1	−0.6	−0.52	N	N	COPD
20	73	1987	3	3	2	+	+	−	−	+	+	+			15	−			−1.2	−1.3		−0.7	−0.95		N	N
21^1-151	51	1987	3	2	10	ND	−	−	−	+	−	−			−	−			−0.5	−0.2		−0.55	−0.9		N	N
22	36	1989	1	0	0	ND	+	−	−	+	+	+	+		−	−	−		−1.8	−1.8	−0.06	0	−0.5	0.41	N	N	N
23^1-151	73	1987	5	10	20	+	−	−	−	+	+	+			−	−			0.5	0.2		−0.35	−0.85		N	N
24^1-150	48	1987	2	0	0	+	+	+	+	+	+	+	+		−	−	−		−2.1	−2.3	−0.52	−0.35	−0.55	−0.38	N	N	N
25	68	1986	6	0	5	ND	+	+	+	+	−	−	+		−	−	−		−1.5	−0.8	0.29	−0.2	−0.4	0.45	N	N	N
26^1-151	72	1987	1	5	3	ND	ND	−	−	+	+	+			−	−			−0.2	−0.8		−0.55	−0.9		N	N
27	50	1987	2	0	0	ND	+	−	−	+	−	−	+		20	20	20		0.6	0.5	0.44	0.2	−0.3	1.1	N	N	N
28	38	1985	2	0	0	+	+	+	+	+	−	−	+		−	−	−		−0.4	−0.9	0.02	−0.2	−0.4	0.66	N	N	N
29	66	1987	4	4	4	+	−	−	−	+	−	−	+		−	−	−		0.1	−0.5	0.61	0.25	0	2.38	N	N	N
30	51	1988	1	0	12	ND	−	−	−	+	−	−	−		−	−	−		−1.4	−1.5	−0.18	0.2	−0.5	0.31	N	N	N

Duration symptoms = time between first symptoms of SS and diagnosis; RB stain = rose bengal staining; Lip biopsy = focus score >1; Ro = anti-Ro antibody; La = anti-La antibody; Xerostomia = absence of salivary pool under the tongue; (0) (4) (10) = years follow up; Cigs./day = number of cigarettes smoked a day; Tlco = carbon monoxide transfer factor; Kco = transfer coefficient; (SR) = standardised residuals (ref 9),;ND = not done,;CXR = chest radiograph; PT = pleural thickening; FA = fibrosing alveolitis; CM = cardiomegaly; COPD = consistent with chronic obstructive pulmonary disease; N = normal.
↵1-150 Patients treated with oral prednisolone (20 mg daily for one month followed by tapering reduction).
↵1-151 Patients lost to follow up at 10 years. Causes of death (by death certificate) were bronchopneumonia secondary to fibrosing alveolitis (age 67, patient 8), transitional cell carcinoma bladder (age 85, patient 12), cerebrovascular accident (age 77, patient 20 and age 81, patient 9).