Effect of the addition and withdrawal of fenofibrate on serum urate, serum lipids, and uric acid clearance in two patients treated with allopurinol
| Allopurinol (alone) |
Allopurinol + fenofibrate combination |
Allopurinol (fenofibrate withdrawn) | |
| Patient 1 | |||
| Serum urate (mmol/l) | 0.40 | 0.26 | 0.39 |
| Uric acid clearance (ml/min) | 6.4 | 11.5 | 4.7 |
| Total cholesterol (mmol/l) | 7.4 | 5.9 | 7.4 |
| Serum triglycerides (mmol/l) | 1.3 | 1.5 | 2.4 |
| Patient 2 | |||
| Serum urate (mmol/l) | 0.61 | 0.37 | 0.46 |
| Uric acid clearance (ml/min) | 8.0 | 16.4 | 9.0 |
| Total cholesterol (mmol/l) | 5.4 | 4.9 | 5.2 |
| Serum triglyceride (mmol/l) | 2.3 | 2.1 | 1.9 |