Table 2

Adverse effects associated with allopurinol

Patient 1 Patient 2 Patient 3 Patient 4 Patient 5
Age (years)5666365660
Duration of the disease (years)12231629 3.3
Previous duration of treatment (months)5320.5618
Allopurinol maintenance doses (mg/day)300300300300300
CrC (ml/min)115.8921088061.2
Adverse eventRashRashAHSFPELeucocytoclastic vasculitis
Subsequent ULDAllopurinol reinitiatedAllopurinol reinitiatedAllopurinol reinitiated2-150 Allopurinol reinitiatedAllopurinol reinitiated
  • CrC = creatinine clearance; AHS = allopurinol hypersensitivity syndrome; FPE = fixed pigmented drug eruption; ULD = urate lowering drug.

  • 2-150 Allopurinol was reinitiated after the patient received benzobromarone for 6 years without adequate response and after desensitisation, as described in Results section.17